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Nitroglycerin micro-emulsion spray content assaying method and application

A technology of microemulsion spray and nitroglycerin, which can be used in aerosol delivery, medical preparations of non-active ingredients, measuring devices, etc., and can solve problems such as reducing drug efficacy

Inactive Publication Date: 2014-03-26
张剑宇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Nitroglycerin tablets cannot be swallowed, because the swallowed nitroglycerin must pass through the liver during the absorption process, and most of the nitroglycerin is inactivated in the liver, which greatly reduces the efficacy of the drug

Method used

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  • Nitroglycerin micro-emulsion spray content assaying method and application
  • Nitroglycerin micro-emulsion spray content assaying method and application
  • Nitroglycerin micro-emulsion spray content assaying method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0140] Accurately weigh 3g of nitroglycerin, 2.5g of peppermint oil, 15g of Tween-80, 7.5g of absolute ethanol, stir at 25°C at a speed of 350-600r / min until evenly mixed, then add 72g of distilled water, and stir until Clarified, accurately packed into the spray bottle to obtain the nitroglycerin microemulsion spray.

Embodiment 2

[0142] Accurately weigh 4g of nitroglycerin, 4g of mint oil, 20g of Tween-80, 10g of absolute ethanol, stir at 25°C at a speed of 350-600r / min until evenly mixed, then add 62g of distilled water, stir until clear, Accurately put into the spray bottle to get the nitroglycerin microemulsion spray.

Embodiment 3

[0144] Accurately weigh 5g of nitroglycerin, 5g of mint oil, 30g of Tween-80, 14.5g of absolute ethanol, stir at 25°C at a speed of 350-600r / min until evenly mixed, then add 45.5g of distilled water, and stir until Clarified, accurately packed into the spray bottle to obtain the nitroglycerin microemulsion spray.

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Abstract

The invention discloses a nitroglycerin micro-emulsion spray content assaying method. The method is an HPLC (High Performance Liquid Chromatography) method; the chromatographic conditions comprise: taking a Diamonsil C18 column (250 mm * 4.6 mm, 5 Mum) as a chromatographic column, taking acetonitrile-water at the ratio of 70:30 as a moving phase, the flow rate being 1.0 mL / min, the detection wave length being 215 nm, and the column temperature being 30 DEG C. The method is good in specificity, accuracy and day to day precision, and can be used for nitroglycerin micro-emulsion spray content assaying and quality monitoring.

Description

[0001] The patent application of the present invention is a divisional application, the original application number is 201210026459.X, the application date is February 7, 2012, and the title of the invention is: a nitroglycerin microemulsion spray and its preparation method and application. technical field [0002] The invention relates to a content determination method and application of a nitroglycerin microemulsion spray, in particular to a content determination method of a nitroglycerin microemulsion spray with good specificity, accuracy and day-to-day precision. technical background [0003] Nitroglycerin is one of the drugs of choice for the treatment of angina. Angina pectoris is a clinical syndrome characterized by episodic chest pain or chest discomfort caused by acute and temporary myocardial ischemia and hypoxia due to coronary insufficiency. The mechanism of action of nitroglycerin to control the attack of angina pectoris is mainly to expand the coronary arteries...

Claims

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Application Information

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IPC IPC(8): G01N30/02A61K9/12A61K31/21A61K47/46A61K47/12A61K47/14A61K47/26A61K47/10A61P9/10
Inventor 张剑宇冯前进张凯
Owner 张剑宇
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