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Application of CUG-BP1 (cytosine-uridineguanine-binding protein 1) and gene thereof in preparation of products for controlling and treating muscle atrophy diseases

A CUG-BP1, muscle atrophy technology, applied in gene therapy, muscular system diseases, neuromuscular system diseases, etc., can solve problems such as skeletal muscle atrophy, limited self-activity, and inability to exercise

Inactive Publication Date: 2014-04-09
INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, for some frail, long-term bedridden or immobilized patients, due to physical conditions and other factors, their own activities are limited, and effective exercise cannot be achieved, which will eventually inevitably lead to skeletal muscle atrophy

Method used

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  • Application of CUG-BP1 (cytosine-uridineguanine-binding protein 1) and gene thereof in preparation of products for controlling and treating muscle atrophy diseases
  • Application of CUG-BP1 (cytosine-uridineguanine-binding protein 1) and gene thereof in preparation of products for controlling and treating muscle atrophy diseases
  • Application of CUG-BP1 (cytosine-uridineguanine-binding protein 1) and gene thereof in preparation of products for controlling and treating muscle atrophy diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Example 1. Application of CUG-BP1 protein or its gene in the regulation and treatment of muscular atrophy diseases

[0058] 1. Construction of muscle atrophy model in neurotomy mice

[0059] The mice were anesthetized by intraperitoneal injection of 0.1ml 5% chloral hydrate, the epidermis of the hind limbs was depilated, and the skin surface was wiped and disinfected with 75% ethanol. The two hind limbs of the mouse were fixed with adhesive tape, and a 2-3 mm incision was made on the inner skin of the hind limb, and the epidermis and skeletal muscle tissue were bluntly separated until the total motor nerve cluster of the hind limb was exposed. Cut off a section of 2-3 mm of the total motor nerve cluster, and immediately suture the muscle tissue and epidermal tissue to obtain a muscle atrophy model in nerve-cut mice. In mice in the control group, the total motor nerve clusters of the hind legs were also exposed but not damaged, and the muscles and epidermis were sutured...

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Abstract

The invention discloses application of CUG-BP1 (cytosine-uridineguanine-binding protein 1) and a gene thereof in preparation of products for controlling and treating muscle atrophy diseases. The invention provides application of a substance for silencing expression of CUG-BP1 or a coding gene thereof in preparation of products for treating muscle atrophy diseases, wherein an amino acid sequence of the CUG-BP1 is shown in a sequence 7 in a sequence table. The experiment proves that the muscle atrophy degree is reduced by silencing the CUG-BP1 in a cut nerve-induced mouse muscle atrophy model, the muscle atrophy can be reduced by silencing the expression of the protein or the coding gene thereof, and the substance used for silencing the protein or the coding gene thereof can be used for preparing the products for treating the muscle atrophy diseases.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to the application of a CUG-BP1 protein or its gene in the preparation and regulation of products for the treatment of muscular atrophy diseases. Background technique [0002] Skeletal muscle is the largest tissue in the human body, and the contraction and relaxation of skeletal muscle is the basis of human motor function. The basic unit of skeletal muscle is the skeletal muscle cell, which is a special multinucleated cell that is fibrous, so it is commonly called skeletal muscle fiber. The type, shape, quantity and metabolic state of skeletal muscle fibers directly determine its exercise capacity. Muscular dystrophy (MD) refers to a group of diseases that damage the muscles of the human body. Muscular dystrophy manifests as progressive skeletal muscle wasting, loss of muscle protein, and death of muscle cells or tissues. As the incidence of muscular atrophy increases year by year, t...

Claims

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Application Information

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IPC IPC(8): A61K48/00A61P21/00C12N15/113C12N15/11C12N15/63
Inventor 王会文姬广聚唐迎龙
Owner INSITUTE OF BIOPHYSICS CHINESE ACADEMY OF SCIENCES
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