Top type stirring bioreactor

Abstract

The invention discloses a top type stirring bioreactor which comprises a tank body, a base, an end closure in sealing connection with the tank body, and a top type mixer, wherein the top type mixer is arranged at the top end of the tank body, and the lower end of the top type mixer extends into the tank body. The top type mixer comprises a drive head, a motor fixedly arranged at the top of the end enclosure, a drive shaft, a sealing sleeve and an impeller; the drive head is arranged at the upper end of the motor, a rotating shaft of the motor is connected with the upper end of the drive shaft, the sealing sleeve is arranged at the middle of the drive shaft, and the impeller is arranged at the bottom end of the drive shaft. By adopting the technical scheme, the top type stirring bioreactor is low in energy consumption, and effectively avoids the flowing dead angle of a two-phase flow. By adopting the top type stirring bioreactor, a strain is good in growth uniformity, and the top type stirring bioreactor is little in damage to hypha of the strain.

Description

technical field [0001] The invention relates to a bioreactor, in particular to an overhead stirring bioreactor. Background technique [0002] A bioreactor is a device system that uses the biological functions of enzymes or organisms (such as microorganisms) to perform biochemical reactions in vitro. It is a biological function simulator, such as a fermenter, immobilized enzyme or immobilized cell reactor Wait. It has important applications in alcohol, pharmaceutical production, and degradation of organic pollutants. At present, there are two types of bioreactors widely used: mechanical stirring type and air lift type. The mechanically stirred bioreactor breaks the air through mechanically stirred paddles, and at the same time mixes the air bubbles evenly with the fermentation liquid composed of bacteria, water, and culture medium. The main problems are complex structure and difficult operation and maintenance. The energy consumption is large, and the shearing force of the...

AI Technical Summary

Problems solved by technology

The mechanically stirred bioreactor breaks the air through mechanically stirred paddles, and at the same time mixes the air bubbles evenly with the fermentation liquid composed of bacteria, water, and culture medium. The main problems are complex structure and difficult operation and maintenance. The energy consumption is large, and the shearing force of the blade is large, which is easy to damage the hyphae

Another type of air-lift bioreactor uses compressed air as the single energy source, and the gas-liquid mixing is completed in the guide tube or the circulation tube. In order to prolong the contact time between the air and the fermentation liquid, the height-to-diameter ratio of the reactor is large. The liquid column increases, the intake pressure increases, the energy consumption of the air compressor increases, and two-phase flow flow dead ends are prone to appear, resulting in uneven growth of bacteria and affecting the fermentation effect. It can be seen that the existing bioreactor Low production efficiency and high energy consumption

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