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Preparation method of Paeonia suffruticosa kidney-tonifying tablets

A technology for invigorating the kidney and chrysanthemum, which can be applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulations, etc., can solve the problems of loose and cracked red chrysanthemum and kidney-invigorating tablets, and achieve a consistent sheet shape and a complete and smooth surface. , uniform color effect

Inactive Publication Date: 2014-05-07
GUANGDONG XIANQIANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the present invention is to provide a preparation method of Hongju Bushen Tablets, which solves the problem that Hongju Bushen Tablets are prone to cracking during tablet compression

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] A preparation method of Hongju Tonifying Kidney Tablets, comprising the steps of:

[0015] (1) Take by weighing Patrinia 960g, Rhodiola Rosea 640g, Semen Shayuan 720g, Chrysanthemum 400g, Semen Cassiae (fried) 600g;

[0016] (2) Add 8 times the weight of medicinal materials in 50% ethanol aqueous solution to Patrinia and Rhodiola, reflux extraction twice, each time for 1.5 hours, filter, and the filtrate recovers ethanol under reduced pressure, and concentrates under reduced pressure to obtain clear paste 1;

[0017] (3) Add Semen Fructus, Chrysanthemum and Semen Cassiae to the medicinal residues after Patrinia and Rhodiola reflux extraction, add 8 times the weight of medicinal materials to decoct and extract, extract twice, each time for 1.5 hours, filter and combine Filtrate, the filtrate was concentrated under reduced pressure to obtain clear paste 2;

[0018] (4) Combine clear cream 1 and clear cream 2, mix well, continue to concentrate to get clear cream 3, spray ...

Embodiment 2

[0020] A preparation method of Hongju Tonifying Kidney Tablets, comprising the steps of:

[0021] (1) Take by weighing Patrinia 960g, Rhodiola Rosea 640g, Semen Shayuan 720g, Chrysanthemum 400g, Semen Cassiae (fried) 600g;

[0022] (2) Add 80% ethanol aqueous solution of 5 times the weight of medicinal materials to Patrinia and Rhodiola, reflux extraction twice, each time for 1.5 hours, filter, and the filtrate recovers ethanol under reduced pressure, and concentrates under reduced pressure to obtain clear paste 1;

[0023] (3) Add Semen Fructus, Chrysanthemum and Semen Cassiae to the medicinal residues after Patrinia and Rhodiola reflux extraction, add 12 times the weight of medicinal materials to decoct and extract, extract twice, each time for 1.5 hours, filter and combine Filtrate, the filtrate was concentrated under reduced pressure to obtain clear paste 2;

[0024] (4) Combine clear cream 1 and clear cream 2, mix well, continue to concentrate to get clear cream 3, spray...

Embodiment 3

[0026] A preparation method of Hongju Tonifying Kidney Tablets, comprising the steps of:

[0027] (1) Take by weighing Patrinia 960g, Rhodiola Rosea 640g, Semen Shayuan 720g, Chrysanthemum 400g, Semen Cassiae (fried) 600g;

[0028] (2) Add 60% ethanol aqueous solution of 7 times the weight of the medicinal materials to Patrinia and Rhodiola, reflux extraction twice, each time for 1.5 hours, filter, and the filtrate recovers ethanol under reduced pressure, and concentrates under reduced pressure to obtain clear paste 1;

[0029] (3) Add Fructus Chrysanthemum, Chrysanthemum and Semen Cassiae to the medicinal residues extracted from Patrinia and Rhodiola, add 9 times the weight of the medicinal materials to decoct and extract, extract twice, each time for 1.5 hours, filter and combine Filtrate, the filtrate was concentrated under reduced pressure to obtain clear paste 2;

[0030] (4) Combine clear cream 1 and clear cream 2, mix well, continue to concentrate to clear cream 3, spr...

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PUM

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Abstract

The invention discloses a preparation method of Paeonia suffruticosa kidney-tonifying tablets, and the preparation method comprises the following steps: (1) weighing Herba Patriniae, Rhodiola sacra, Astragalus complanatus seed, Chrysanthemum morifolium flower, and Semen Cassiae (Cassia obtusifolia and / or Cassia tora) (parched); (2) adding an ethanol aqueous solution to Herba Patriniae and Rhodiola sacra, performing reflux extraction, filtering, recovering ethanol, and concentrating to obtain an extract I; (3) adding other medicinal materials to medicinal residues, adding water for decoction extraction, filtering, mixing filtrates, and concentrating medicinal liquid to obtain an extract 2; (4) mixing the extract 1 and the extract 2, concentrating to obtain an extract 3, spray-drying, mixing medicinal powder, starch and sugar powder proportionally, adding proper amount of binder, granulating, drying, tabletting, and coating. The preparation method disclosed by the invention can be used for improving the process, solving the problem that the existing Paeonia suffruticosa kidney tonifying tablets are easy to loose and crack during granulation with high-concentration ethanol, improving compressibility, and reducing loose and crack phenomena during tabletting. The Paeonia suffruticosa kidney tonifying tablets prepared by using the preparation method disclosed by the invention are convenient in administration, have a distinct therapeutic effect, and can be used for treating both symptoms and root causes, so as to meet the needs of patients.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, and in particular relates to a preparation method of Hongju Bushen Tablets. Background technique [0002] Binders and wetting agents play an important role in granulation, and their selection and dosage will directly affect the quality of granules. The choice of binder and wetting agent should depend on the nature of the powder. If the amount of binder is too small, too much fine powder will produce loose flakes. The whole extract powder of traditional Chinese medicine generally has a high viscosity, and it is easy to absorb moisture due to the influence of the environment and climate. It is very difficult to granulate starch slurry by conventional methods, and it will form lumps, which cannot be dispersed, granulated or sieved. However, when high-concentration ethanol is used for granulation, cracking is easy to occur, and the use of high-concentration ethano...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K36/482A61K47/36A61K47/10A61P25/00A61P3/06A61P1/14A61P11/10
Inventor 彭珍香张志生杜丽丽付培荣黄彩逢邱思婕
Owner GUANGDONG XIANQIANG PHARMA
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