The invention provides a temperature-resistant and salt-resistant lubricating drag reducer for drilling fluid and a preparation method of the temperature-resistant and salt-resistant lubricating dragreducer. The composition comprises the following components in parts by mass: 60-80 parts of base oil, 20-40 parts of fatty acid amide, 3-5 parts of oleic acid monoglyceride, 1-3 parts of fatty acid alcohol amine, 1-3 parts of triethanolamine and 1-3 parts of triethanolamine. The base oil comprises any one or a mixture of more of biodiesel, white oil, vegetable oil, animal oil and mineral oil, thefatty acid alcohol amine comprises any one or a mixture of more of C4-8 alcohol amine, triethanolamine and a C10-18 fatty acid mixture, and the preparation method comprises the following steps: weighing the base oil, and putting the base oil into a reactor; adding fatty acid amide into the base oil, and uniformly stirring; adding oleic acid monoglyceride, and uniformly stirring; adding fatty acidalcohol amine, and uniformly stirring; and performing continuous stirring reaction for 30 min. The friction resistance between a drill stem and rock can be greatly reduced, abrasion of a drilling tool and other metal parts is reduced, rotation resistance is reduced, and the oil-gas drill bit has the advantages of temperature resistance, salt resistance, friction resistance reduction, adhesion coefficient reduction and the like, and can meet the requirement for smooth development of oil-gas drills.