Utilize saikosaponin A to prepare the method for clemastine fumarate gel preparation
A technology of saikosaponin and statin gel, which is applied in the field of gel preparation to achieve the effects of good biodegradability, high mechanical strength and stability, and mild reaction conditions
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Embodiment 1
[0015] Utilize saikosaponin A to prepare the method for clemastine fumarate gel preparation, comprise the following steps:
[0016] Step 1. Take 1g of saikosaponin a, add 20ml of distilled water, grind finely, then add 30ml of distilled water, and stir ultrasonically for 3 hours to make it fully swell to obtain a swelling solution for later use;
[0017] Step 2, take 0.2g polysorbate 80 and 0.4g sodium hydroxide, dissolve in 10ml distilled water, and add the swelling liquid obtained in step 1 to grind, grind evenly to get the grinding liquid, set aside;
[0018] Step 3: Dissolve 0.1 g of clemastine fumarate and 1 g of azone in 5 ml of ethanol solution, then gradually add to the grinding liquid obtained in Step 2, stir evenly, then add 15 ml of distilled water, stir evenly and remove air bubbles, Placed at 25°C for 3 hours, then placed at 40°C for 20 hours for cross-linking, and after standing, a clemastine fumarate gel preparation with saikosaponin a as the gel matrix was obta...
Embodiment 2
[0020] Utilize saikosaponin A to prepare the method for clemastine fumarate gel preparation, comprise the following steps:
[0021] Step 1. Take 1g of saikosaponin a, add 50ml of distilled water, grind finely, then add 50ml of distilled water, and stir ultrasonically for 5 hours to make it fully swell to obtain a swelling solution for later use;
[0022] Step 2, take 0.2g polysorbate 80 and 0.4g sodium hydroxide, dissolve in 20ml distilled water, and add the swelling liquid obtained in step 1 to grind, grind evenly to obtain the grinding liquid, set aside;
[0023] Step 3: Dissolve 0.1 g of clemastine fumarate and 1 g of azone in 10 ml of ethanol solution, then gradually add to the grinding solution obtained in Step 2, stir evenly, then add 25 ml of distilled water, stir evenly and remove air bubbles, Place at 25°C for 5 hours, then place at 40-50°C for 30 hours for cross-linking, and after standing, a clemastine fumarate gel preparation with saikosaponin a as the gel matrix c...
Embodiment 3
[0025] Utilize saikosaponin A to prepare the method for clemastine fumarate gel preparation, comprise the following steps:
[0026] Step 1. Take 1g of saikosaponin a, add 35ml of distilled water, grind it finely, then add 40ml of distilled water, and stir it ultrasonically for 4 hours to fully swell it to obtain a swelling solution for later use;
[0027] Step 2, take 0.2g polysorbate 80 and 0.4g sodium hydroxide, dissolve in 15ml distilled water, and add the swelling liquid obtained in step 1 to grind, and grind evenly to obtain the grinding liquid, set aside;
[0028] Step 3: Dissolve 0.1 g of clemastine fumarate and 1 g of azone in 5 ml of ethanol solution, then gradually add to the grinding solution obtained in Step 2, stir evenly, then add 20 ml of distilled water, stir evenly and remove air bubbles, Place it at 25°C for 4 hours, then place it at 45°C for 25 hours for cross-linking, and after standing, you can get the clemastine fumarate gel preparation with saikosaponin ...
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