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Improved preparation method of placenta polypeptide for injection

A technology of placental polypeptide and placenta, which is applied to the preparation method of peptides, medical preparations containing active ingredients, chemical instruments and methods, etc., can solve problems such as product composition differences, reduce composition differences, simplify process steps, and simplify grinding The effect of craft

Inactive Publication Date: 2014-05-14
CHINA INST FOR RADIATION PROTECTION
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Problems solved by technology

[0005] However, in the process of production practice, technicians found that although the placental polypeptide prepared by the method of preparing placental polypeptide for injection has greatly improved compared with the traditional process (boiling at high temperature, concentration under reduced pressure, etc.), there are still differences in product composition between batches. wait for some deficiencies

Method used

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Embodiment Construction

[0020] The present invention will be described in detail below in conjunction with specific embodiments.

[0021] The preparation method of the improved placental polypeptide provided by the present invention is an improvement on the "Preparation Method of Placental Polypeptide for Injection" 200610150755.5, including the following steps:

[0022] (1) Collect the placentas from the placentas of healthy puerperas who gave birth at term, and after testing for viruses such as hepatitis B, hepatitis C, AIDS, and syphilis, screen the placenta with negative virus test results as raw materials;

[0023] (2) After the fascia is removed from the qualified placental tissue, squeeze or knead it fully, collect the placental blood, and wash the placental tissue repeatedly with water for injection (the amount of flushing water is determined according to the size of the placental tissue); after fully washing , put the placental blood and flushing water into the container, mix them evenly, an...

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Abstract

The invention relates to a preparation method of a biology preparation, and specifically relates to a preparation method of placenta polypeptide for injection. The method takes use of placental blood in placenta of full term delivery of healthy parturient, and comprises the steps of inactivating bacteria, separating by centrifugation, clarifying and filtering, carrying out ultra filtration, sterilizing and filtering and freeze-drying. A process is simplified; production efficiency is increased; component differences among bathes of products are reduced; and quality indexes such as product activity are increased.

Description

technical field [0001] The invention relates to a preparation method of a biological preparation, in particular to a preparation method of an improved placental polypeptide. Background technique [0002] Placental preparations currently on the market, such as placental tissue injection, are mainly produced using traditional Chinese medicine processing methods, such as extraction by high temperature boiling, concentration under reduced pressure, etc. In addition, some units use HBVM-AgB negative and HbsAb positive placenta as raw materials The placental preparation is prepared by low-temperature extraction process for the treatment of hepatitis B. [0003] The former is easy to inactivate the virus that may remain in the product, so as to ensure the safety of the product, but because it is operated at high temperature, it is also extremely easy to reduce or reduce the activity in the product. The latter is just the opposite of the former. Due to the low temperature operation...

Claims

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Application Information

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IPC IPC(8): A61K38/00A61P31/20A61P1/16C07K1/14C07K1/34A61K35/50
Inventor 赵怀璞安全李炜宾田宇刘云霞崔梅兰贾雪张继荣
Owner CHINA INST FOR RADIATION PROTECTION
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