Synthesis method for pesticide intermediate trifluoroacetonitrile

A technology of trifluoroacetonitrile and synthesis method, applied in the dehydration preparation of carboxylic acid amide, organic chemistry, etc., can solve problems such as unfavorable heat transfer, achieve the effects of reducing costs, safe and mild reaction conditions, and increasing yield

Inactive Publication Date: 2014-05-21
JIANGSU INST OF ECOMONES
View PDF4 Cites 12 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The reaction of preparing trifluoroacetonitrile by dehydration of trifluoroacetamide has a high yield in the laboratory stage, but there are many risk fac

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0018] 100Kg trifluoroacetamide, 180Kg carbon tetrachloride and 200L trifluoroacetic anhydride were added to a 1000L gas reactor, and the temperature was slowly raised to 160°C, and the gas produced immediately was trifluoroacetonitrile.

[0019] The use of trifluoroacetic anhydride can overcome the shortcomings of other water loss agents, such as polyphosphoric acid, which has poor fluidity even after heating due to its high viscosity.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention provides a synthesis method for a pesticide intermediate trifluoroacetonitrile. The synthesis method comprises the following steps: adding trifluorofluoroacetamide, carbon tetrachloride and trifluoroacetic anhydride into a gas reaction kettle; raising the temperature to 150-180 DEG C; dehydrating and reacting; and cooling to obtain the trifluoroacetonitrile. A reaction formula is as follows: CF3CONH2+PPh3+CCl4->CF3C(Gl)=NH+O=PPh3+CHCl3CF3C(Cl)=NH+PPH3->CF3CN+PPh3+HCl.

Description

technical field [0001] The present invention relates to a kind of synthetic method of trifluoroacetonitrile. Background technique [0002] As an active electrophile, trifluoroacetonitrile is widely used in the synthesis of trifluoromethyl-containing heterocyclic compounds, and is an important chemical intermediate. With the continuous development of fluorine-containing pesticides and medicines, trifluoromethyl-containing heterocyclic compounds The types of heterocyclic compounds are increasing day by day, and the demand is also gradually increasing, so trifluoroacetonitrile has a wide range of applications in pesticides and medicine. The research and development and production of trifluoroacetonitrile were carried out earlier in foreign countries, such as Daikin Corporation in Japan and Halocarbon Corporation in the United States. However, the industrialized production of trifluoroacetonitrile has not been realized in China, and it is necessary to import trifluoroacetonitri...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): C07C255/10C07C253/20
Inventor 孔繁蕾张旺庚丁武松
Owner JIANGSU INST OF ECOMONES
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap