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Use of arctigenin in preparing medicine for treating autoimmune hepatitis

A technology of arctigenin and autoimmunity, applied in the field of medicine, can solve the problems such as the application of arctigenin that has not been reported, and achieve significant therapeutic and preventive effects, low price, and the effect of reducing liver tissue damage.

Active Publication Date: 2016-08-17
LUNAN PHARMA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It has been proved that arctigenin has stronger biological activity than arctiin, such as significant antibacterial, antiviral, antitumor, anti-PAF receptor and calcium antagonistic activities, but arctigenin has not been reported in the prior art Application in preparation of autoimmune hepatitis medicine

Method used

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  • Use of arctigenin in preparing medicine for treating autoimmune hepatitis
  • Use of arctigenin in preparing medicine for treating autoimmune hepatitis
  • Use of arctigenin in preparing medicine for treating autoimmune hepatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 arctigenin injection

[0022] prescription:

[0023] Arctigenin 10g

[0024] PEG-400 2g

[0025] 0.9% Sodium Chloride Solution Add to 10L

[0026] Preparation Process:

[0027] Add the prescribed amount of PEG-400 to arctigenin, stir to dissolve, add the prescribed amount of 0.9% sodium chloride solution, stir evenly, adjust the pH to 3 with citric acid, add 0.5% activated carbon for needles, stir, and decarbonize, that is have to.

Embodiment 2

[0028] Embodiment 2 arctigenin injection

[0029] prescription:

[0030] Arctigenin 10g

[0031] PEG-400 3g

[0032] 0.9% Sodium Chloride Solution Add to 10L

[0033] Preparation Process:

[0034] Add the prescribed amount of PEG-400 to arctigenin, stir to dissolve, add 0.9% sodium chloride solution to 10L, stir evenly, adjust the pH to 4 with citric acid, add 0.5% activated carbon for needles, stir, and decarbonize to obtain . Embodiment 3 arctigenin injection

Embodiment 3

[0034] Add the prescribed amount of PEG-400 to arctigenin, stir to dissolve, add 0.9% sodium chloride solution to 10L, stir evenly, adjust the pH to 4 with citric acid, add 0.5% activated carbon for needles, stir, and decarbonize to obtain . Embodiment 3 arctigenin injection

[0035] prescription:

[0036] Arctigenin 10g

[0037] PEG-400 1g

[0038] Add water for injection to 10L

[0039] Preparation Process:

[0040] Add the prescribed amount of PEG-400 to arctigenin, stir to dissolve, add water for injection to 10L, stir evenly, adjust the pH to 6.5 with citric acid, add 0.5% activated carbon for needles, stir, and decarbonize to obtain the product.

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PUM

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Abstract

The invention provides a use of arctigenin in preparing a medicine for treating autoimmune liver diseases, and belongs to the field of medicine. Arctigenin is an effective traditional Chinese medicine monomer obtained by extracting from a traditional Chinese medicine fructus arctii; when being used in treatment of the autoimmune liver diseases, arctigenin can significantly improve the proportion of immune cell factors of a patient, significantly reduces the aminotransferase level and the liver index of the patient, thereby playing effects of simultaneous treatment of principal and subordinate symptoms on the autoimmune liver diseases especially autoimmune hepatitis. Arctigenin has small toxic and side effect in a drug use process, and is definite in therapeutic effect, low in price and quite wide in medical application prospects.

Description

technical field [0001] The invention belongs to the field of medicine, and relates to a medical use of arctigenin, in particular to the use of arctigenin in preparing aglycone medicine for treating autoimmunity. Background technique [0002] Autoimmune liver disease is a type of autoimmune disease in which the liver is a relatively specific immunopathologically damaged organ. With the improvement of understanding and diagnosis level, the prevalence of autoimmune liver disease reported at home and abroad is increasing year by year, so it has been paid more and more attention and attention. It mainly includes: autoimmune hepatitis, primary biliary cirrhosis and primary sclerosing cholangitis, and any overlap syndrome between any two of these three diseases, often accompanied by extrahepatic immune diseases, and Diagnosis is based on specific biochemical abnormalities, autoantibodies, and dry tissue features. Among them, autoimmune hepatitis is the most common, and its liver ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/365A61K9/08A61P37/02A61P29/00A61P1/16
Inventor 赵志全王恩力牟丽丽
Owner LUNAN PHARMA GROUP CORPORATION
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