Preparation method of multifunctional liposome vesicle
A liposome vesicle, multi-functional technology, applied in liposome delivery, preparations for in vivo tests, medical preparations of non-active ingredients, etc.
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Embodiment 1
[0026] A preparation method of the multifunctional liposome vesicles, the steps are as follows:
[0027] 1) Dissolve DPPC and cholesterol in chloroform according to the ratio of 3:1, so that the final concentration of DPPC is 5 mmol / L. Dry under vacuum for at least 6 hours;
[0028] 2) Add SC4AB aqueous solution with a concentration of 0.25 mmol / L equal to the volume of chloroform to the above liposome film, stir at 55-60°C for 30 minutes, then sonicate in a water bath for 30 minutes, and finally use a 220 nm filter to remove large lipid particles Plastids can be used to prepare multifunctional liposome vesicles.
Embodiment 2
[0030] A preparation method of the multifunctional liposome vesicles, the steps are as follows:
[0031] 1) Dissolve DPPC and cholesterol in chloroform according to the ratio of 3:1, so that the final concentration of DPPC is 5 mmol / L. Dry under vacuum for at least 6 hours;
[0032] 2) Add SC4AB aqueous solution with a concentration of 0.5 mmol / L equal to the volume of chloroform to the above liposome film, stir at 55-60°C for 30 minutes, then sonicate in a water bath for 30 minutes, and finally use a 220 nm filter to remove large lipid particles Plastids can be used to prepare multifunctional liposome vesicles.
Embodiment 3
[0047] A method for functional derivatization of the multifunctional liposome vesicles, the steps are as follows:
[0048] The multifunctional liposome vesicle solution prepared in Example 2 was diluted 10 times, and methyl viologen was added to the final concentration of 0.05 mmol / L, and mixed evenly.
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