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A jujube extract based on a combination of two jujube varieties and its application in alleviating neurodegenerative diseases and antidepressant

A technology for extracts and jujubes, which is applied in the application fields of jujube extracts, alleviating neurodegenerative diseases and anti-depression, can solve problems such as inability to correspond to quality control index components, backward detection methods, etc., to ensure prevention or treatment. Effect, quality stable and controllable effect

Active Publication Date: 2017-01-04
THE AWARENESS OF NATURE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Based on the current extraction process, there are the following problems: conventional water or ethanol water is suitable for the extraction of nucleoside components, and there is no report on the use of surfactants to promote the extraction of insoluble flavonoids; or to extract nucleosides with water or ethanol water flavonoids or flavonoids, and there is no extraction process that takes the two types of components as comprehensive indicators; there are still relatively backward detection methods, such as the use of spectrophotometers to determine total flavonoids, which will lead to quality control index components that cannot correspond to medicinal ingredients.

Method used

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  • A jujube extract based on a combination of two jujube varieties and its application in alleviating neurodegenerative diseases and antidepressant
  • A jujube extract based on a combination of two jujube varieties and its application in alleviating neurodegenerative diseases and antidepressant
  • A jujube extract based on a combination of two jujube varieties and its application in alleviating neurodegenerative diseases and antidepressant

Examples

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Effect test

Embodiment 1

[0056] Preparation method of jujube extract: take Zanhuang jujube and Jishanban jujube, mix them in a mass ratio of 3:1, grind them, and extract twice with an aqueous solution containing 0.5% (w / v) of surfactant poloxamer 188 , 3 hours each time, filtered, combined filtrates, and lyophilized. After determination, the contents of nucleosides and flavonoids in each gram of jujube extract are 830 micrograms and 90 micrograms respectively.

Embodiment 2

[0058] The preparation method of jujube extract: take Gouda jujube and Fuping jujube, mix them at a mass ratio of 1:1, grind them, and extract twice with an aqueous solution containing 1.0% (w / v) of surfactant Tween-80, each time After 1 hour, filter, combine the filtrates, concentrate the filtrates, and set aside. After determination, the contents of nucleosides and flavonoids in each gram of jujube extract are 800 micrograms and 200 micrograms respectively.

Embodiment 3

[0060] The preparation method of jujube extract: take Gouda jujube and Fuping jujube, mix them at a mass ratio of 1:1, grind them, and extract twice with an aqueous solution containing 0.5% (w / v) of surfactant Tween-80, each time After 1 hour, filter, combine the filtrates, concentrate the filtrates, and set aside. After determination, the contents of nucleosides and flavonoids in each gram of jujube extract are 805 micrograms and 190 micrograms respectively.

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Abstract

The invention provides a Chinese date extractive, and particularly relates to a preparation method for the Chinese date extractive and application of the Chinese date extractive in remission of neurodegenerative disease, anti-depression, nerve growth factor like action and promotion of neurotrophic factor expression. The Chinese date extractive is extracted from the raw material combined by two well-chosen Chinese date cultivated varieties, wherein the mass ratio of the two well-chosen Chinese date cultivated varieties is (5:1)-(1:5); 1g of the Chinese date extractive contains 500mcg of nucleosides and 60mu g of flavones. The Chinese date extractive adopts the raw material combined by optimized Chinese date cultivated varieties, and the extraction method can guarantee extraction of the nucleosides and flavones, so that the Chinese date extractive can better play the role in preventing and treating nerve diseases like neurodegenerative disease and anti-depression as well as play the health role.

Description

technical field [0001] The present invention relates to the technical field of traditional Chinese medicine, in particular to an extract based on optimizing the combination of two jujube cultivars, and more specifically to a jujube extract prepared from a combination of two preferred cultivars of jujube as raw materials. The present invention also includes the Preparation method of jujube extract and its application in alleviating neurodegenerative diseases and antidepressant. Background technique [0002] Neurodegenerative disease, a disease state in which cells and neurons of the brain and spinal cord are lost, is a chronic, progressive disease of the nervous system. Its common diseases mainly include Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis and Huntington's disease. Such diseases are age-related diseases, and the incidence rate increases year by year with the increase of the aging population. Its harm to the living ability of patients is s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/725A23L33/00A61P25/00A61P25/24
Inventor 陈剑平詹华強吴纪嬅董婷霞彭靖淳
Owner THE AWARENESS OF NATURE