Compound glycyrrhizin medicinal composition for injection and preparation method thereof
A compound glycyrrhizin and glycyrrhizin technology are applied in the compound glycyrrhizin pharmaceutical composition for injection and preparation thereof, and the field of pharmaceutical composition for injection and preparation thereof, can solve the problems of limited solubilization effect and the like, and achieve safety Enhanced, rapid reconstitution, sustained stability, high physiological tolerance
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Embodiment 1
[0036] Example 1 Prescription of Compound Glycyrrhizin for Injection (in 1000 sticks, unit: g)
[0037] Glycyrrhizin
[0038]Preparation process: Add 700ml of water for injection into a stainless steel container, control the temperature of the water for injection at 45°C to 60°C, add 8g of sodium sulfite, 50g of polyethylene glycol 15-hydroxystearate in turn, stir to dissolve completely; add 20g of licorice Add 200g glycine, stir to dissolve completely; add 10g L-cysteine hydrochloride, stir to dissolve completely; measure the pH value of the solution, adjust the pH value to 6.2 with 10% sodium hydroxide solution ~6.4; add medicinal charcoal with a liquid dosage of 0.1% (w / v), heat and absorb at 45°C~60°C for 15 minutes, stir, and decarbonize by coarse filtration while hot; add water for injection to the full amount, stir evenly, and measure the pH The value range is controlled between 6.0 and 7.5, fine filtration, filling, half-tamping, freeze-drying, capping, lig...
Embodiment 2
[0039] Example 2 Prescription of compound glycyrrhizin for injection (in 1000 sticks, unit: g)
[0040] Glycyrrhizin
[0041] Preparation process: Add 700ml of water for injection into a stainless steel container, control the temperature of the water for injection at 45°C to 60°C, add 8g of sodium sulfite, 250g of polyethylene glycol 15-hydroxystearate in turn, stir to dissolve completely; add 20g of licorice Add 200g glycine, stir to dissolve completely; add 10g L-cysteine hydrochloride, stir to dissolve completely; measure the pH value of the solution, adjust the pH value to 6.2 with 10% sodium hydroxide solution ~6.4; add medicinal charcoal with a liquid dosage of 0.1% (w / v), heat and absorb at 45°C~60°C for 15 minutes, stir, and decarbonize by coarse filtration while hot; add water for injection to the full amount, stir evenly, and measure the pH The value range is controlled between 6.0 and 7.5, fine filtration, filling, half-tamping, freeze-drying, capping, l...
Embodiment 3
[0042] Example 3 Prescription of Compound Glycyrrhizin for Injection (in 1000 sticks, unit: g)
[0043] Glycyrrhizin
[0044] Preparation process: Add 700ml of water for injection into a stainless steel container, control the temperature of the water for injection at 45°C to 60°C, add 40g of sodium sulfite, 50g of polyethylene glycol 15-hydroxystearate in turn, stir to dissolve completely; add 20g of licorice Add 200g glycine, stir to dissolve completely; add 10g L-cysteine hydrochloride, stir to dissolve completely; measure the pH value of the solution, adjust the pH value to 6.2 with 10% sodium hydroxide solution ~6.4; add medicinal charcoal with a liquid dosage of 0.1% (w / v), heat and absorb at 45°C~60°C for 15 minutes, stir, and decarbonize by coarse filtration while hot; add water for injection to the full amount, stir evenly, and measure the pH The value range is controlled between 6.0 and 7.5, fine filtration, filling, half-tamping, freeze-drying, capping, l...
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