A method for rapid determination of the content of Panax notoginseng medicinal material

A technology for rapid determination of Panax notoginseng, which is applied in measurement devices, material separation, analysis of materials, etc., can solve the problems of long inspection cycle, small sampling amount, large error, etc., achieve high accuracy and operability, and stable measurement results Effect

Active Publication Date: 2016-03-23
广东广发制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the "Chinese Pharmacopoeia" (a 2010 edition) the sample pretreatment method for the determination of the content of Panax notoginseng medicinal materials has a small amount of sampling, large errors, and a long inspection cycle, which is not conducive to production control

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A kind of method for quickly measuring the content of Radix Notoginseng medicinal material of the present embodiment, it is measured according to the following steps:

[0040] (1) Preparation of test solution

[0041]Accurately weigh 50.01g of Panax notoginseng crude powder as the test sample 1, add 75% ethanol and heat and extract three times respectively, the volume of the 75% ethanol added in the three heating extractions is 250ml, 100ml, 100ml successively, the temperature of each heating extraction The temperature is 70°C, and the heating and extraction time is 1h each time. The three extracts are filtered with gauze to obtain the filtrate, the filtrates are combined and 75% ethanol is added to make the volume to 500ml, shake well, and the filtrate is obtained by filtration. Add methanol to 5ml of filtrate and dilute to 50ml to prepare the test solution;

[0042] (2) Preparation of reference substance solution

[0043] Precisely weigh ginsenoside R g1 Reference ...

Embodiment 2

[0069] A kind of method for quickly measuring the content of Radix Notoginseng medicinal material of the present embodiment, it is measured according to the following steps:

[0070] (1) Preparation of test solution

[0071] Accurately weigh 50.20g of Panax notoginseng crude powder as the test sample 1, add 75% ethanol and heat and extract three times respectively, the volume of the 75% ethanol added in the three heating extractions is 250ml, 100ml, 100ml in sequence, and the temperature of each heating extraction The temperature is 70°C, and the heating and extraction time is 1h each time. The three extracts are filtered with gauze to obtain the filtrate, the filtrates are combined and 75% ethanol is added to make the volume to 500ml, shake well, and the filtrate is obtained by filtration. Add methanol to 5ml of filtrate and dilute to 50ml to prepare the test solution;

[0072] (2) Preparation of reference substance solution

[0073] Precisely weigh ginsenoside R g1 Refere...

Embodiment 3

[0084]A kind of method for quickly measuring the content of Radix Notoginseng medicinal material of the present embodiment, it is measured according to the following steps:

[0085] (1) Preparation of test solution

[0086] Accurately weigh 50.00g of Panax notoginseng crude powder as the test sample 1, add 75% ethanol and heat and extract three times respectively, the volume of the 75% ethanol added in the three heating extractions is 250ml, 100ml, 100ml successively, the temperature of each heating extraction The temperature is 70°C, and the heating and extraction time is 1h each time. The three extracts are filtered with gauze to obtain the filtrate, the filtrates are combined and 75% ethanol is added to make the volume to 500ml, shake well, and the filtrate is obtained by filtration. Add methanol to 5ml of filtrate and dilute to 50ml to prepare the test solution;

[0087] (2) Preparation of reference substance solution

[0088] Precisely weigh ginsenoside R g1 Reference ...

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Abstract

The present invention relates to the technical field of determination methods for the content of medicinal materials, in particular to a method for rapidly determining the content of the medicinal material Radix Notoginseng, which is determined according to the following steps: (1) Preparation of the test solution: weighing coarse powder of the medicinal material Radix Notoginseng As the test sample, add an organic solvent to heat and extract several times respectively, filter the extracts several times to obtain a filtrate, combine the filtrate and add an organic solvent to constant volume, shake well, filter to obtain a subsequent filtrate, measure the subsequent filtrate and add organic Solvent constant volume, promptly makes need testing solution; (2) preparation of reference substance solution; (3) adopt high performance liquid chromatography to measure. The deviation between the Panax notoginseng total saponins content detected by the method of the present invention and the Panax notoginseng total saponins content detected by the Pharmacopoeia standard method is ≤ 1.4%, which meets the deviation requirements; the Panax notoginseng medicinal material content of the present invention is measured in the preparation of the test product, The sample sampling volume is larger, the error is smaller, and the inspection cycle is shorter than the pharmacopoeia method.

Description

technical field [0001] The invention relates to the technical field of methods for determining the content of medicinal materials, in particular to a method for rapidly determining the content of notoginseng medicinal materials. Background technique [0002] Panax notoginseng is the main drug in the prescription of Fufang Xueshuantong soft capsule. It is the dried root, stem and leaf of Panax notoginseng of Araliaceae plant. It is excavated and washed before the flowers bloom in autumn, and the main root, branch root and rhizome are separated and dried. Panax notoginseng saponins (saponins of Panax notoginseng, PNS) is the main medicinal component of Panax notoginseng, Panax notoginseng saponins are extracted from Panax notoginseng of the Araliaceae plant, and more than 65% of the saponins are Panax notoginseng saponins R 1 , Ginsenoside R g1 and ginsenoside R b1 . Pharmacological studies have shown that Panax notoginseng saponins can reduce the body's oxygen consumption,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/74G01N30/06
Inventor 夏羽周树和
Owner 广东广发制药有限公司
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