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Method for rapidly measuring content of pseudo-ginseng medicinal material

A technology for rapid determination of Panax notoginseng, which is used in measurement devices, material separation, analysis of materials, etc., can solve the problems of long inspection period, small sampling amount, large error, etc., achieve high accuracy and operability, and stable measurement results. Effect

Active Publication Date: 2014-07-02
广东广发制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the "Chinese Pharmacopoeia" (a 2010 edition) the sample pretreatment method for the determination of the content of Panax notoginseng medicinal materials has a small amount of sampling, large errors, and a long inspection cycle, which is not conducive to production control

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] A kind of method for quickly measuring the content of Radix Notoginseng medicinal material of the present embodiment, it is measured according to the following steps:

[0040] (1) Preparation of test solution

[0041]Accurately weigh 50.01g of Panax notoginseng crude powder as the test sample 1, add 75% ethanol to heat and extract three times respectively, the volume of the 75% ethanol added in the three heat extractions is 250 ml, 100 ml, 100 ml in turn, and each heat extraction The temperature is 70°C, and the time for heating and extracting each time is 1h. The extracts are filtered three times with gauze to obtain the filtrate, the filtrates are combined and 75% ethanol is added to make the volume to 500 ml, shake well, and the filtrate is obtained by filtration. Measure 5 ml of the continued filtrate and add methanol to be constant to 50 ml to obtain the test solution;

[0042] (2) Preparation of reference substance solution

[0043] Precisely weigh ginsenoside R...

Embodiment 2

[0069] A kind of method for quickly measuring the content of Radix Notoginseng medicinal material of the present embodiment, it is measured according to the following steps:

[0070] (1) Preparation of test solution

[0071] Accurately weigh 50.20 g of Panax notoginseng crude powder as the test sample 1, add 75% ethanol to heat and extract three times respectively, and the volume of 75% ethanol added in the three times of heat extraction is 250 ml, 100 ml, 100 ml in turn, and each heat extraction The temperature is 70°C, and the time for heating and extracting each time is 1h. The extracts are filtered three times with gauze to obtain the filtrate, the filtrates are combined and 75% ethanol is added to make the volume to 500 ml, shake well, and the filtrate is obtained by filtration. Measure 5 ml of the continued filtrate and add methanol to be constant to 50 ml to obtain the test solution;

[0072] (2) Preparation of reference substance solution

[0073] Precisely weigh gin...

Embodiment 3

[0084]A kind of method for quickly measuring the content of Radix Notoginseng medicinal material of the present embodiment, it is measured according to the following steps:

[0085] (1) Preparation of test solution

[0086] Accurately weigh 50.00 g of Panax notoginseng crude powder as the test sample 1, add 75% ethanol and heat and extract three times respectively, the volumes of 75% ethanol added in the three heating extractions are 250 ml, 100 ml, 100 ml in turn, each heating and extracting The temperature is 70°C, and the time for heating and extracting each time is 1h. The extracts are filtered three times with gauze to obtain the filtrate, the filtrates are combined and 75% ethanol is added to make the volume to 500 ml, shake well, and the filtrate is obtained by filtration. Measure 5 ml of the continued filtrate and add methanol to be constant to 50 ml to obtain the test solution;

[0087] (2) Preparation of reference substance solution

[0088] Precisely weigh ginseno...

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Abstract

The invention relates to the technical field of measurement methods of content of medicinal materials and in particular relates to a method for rapidly measuring the content of a pseudo-ginseng medicinal material. The method comprises the following steps: (1) preparing a test solution, namely weighing crude powder of the pseudo-ginseng medicinal material to serve as a test product, adding an organic solvent, respectively heating and extracting for multiple times, respectively filtering the extracting solutions for multiple times to obtain filtrate, merging the filtrate, adding the organic solvent for metering the volume to be constant, shaking evenly, filtering to prepare subsequent filtrate, measuring the subsequent filtrate, adding the organic solvent for metering the volume to be constant, thereby obtaining the test solution; (2) preparing a reference solution; and (3) measuring by adopting high performance liquid chromatography. The deviation between the content of total saponins in pseudo-ginseng detected by the method and the content of total saponins in pseudo-ginseng detected in a pharmacopoeia criterion method is less than or equal to 1.4 percent, and the deviation requirement is met. Moreover, during measurement of the content of the pseudo-ginseng medicinal material and preparation of the test product, the sampling amount of the sample is high, the error is small, and the detection period is shorter than that by the pharmacopoeia method.

Description

technical field [0001] The invention relates to the technical field of methods for determining the content of medicinal materials, in particular to a method for rapidly determining the content of notoginseng medicinal materials. Background technique [0002] Panax notoginseng is the main drug in the prescription of Fufang Xueshuantong soft capsule. It is the dried root, stem and leaf of Panax notoginseng of Araliaceae plant. It is excavated and washed before the flowers bloom in autumn, and the main root, branch root and rhizome are separated and dried. Notoginseng saponins (saponins of Panax notoginseng, PNS) are the main medicinal components of Panax notoginseng, which are extracted from Panax notoginseng of Araliaceae, and more than 65% of the saponins are notoginseng saponins R 1 , Ginsenoside R g1 and ginsenoside R b1 . Pharmacological studies have shown that Panax notoginseng saponins can reduce the body's oxygen consumption, inhibit platelet aggregation and increa...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/74G01N30/06
Inventor 夏羽周树和
Owner 广东广发制药有限公司
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