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A metronidazole chlorhexidine lotion with improved properties

A technology of metronidazole and chlorhexidine, applied in the field of lotion of metronidazole and chlorhexidine, can solve the problems of long duration of drug action and low irritation, and achieve high bioadhesion and duration of drug action , low irritation, high clinical effect

Active Publication Date: 2016-06-01
JIANGSU SEMPOLL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Specifically, the lotion is mild in nature, low in irritation, and has a long duration of drug action.

Method used

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  • A metronidazole chlorhexidine lotion with improved properties
  • A metronidazole chlorhexidine lotion with improved properties
  • A metronidazole chlorhexidine lotion with improved properties

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036]

[0037] Description: ★, KelcoloidS contains 40% guluronicacid and 60% mannuronic acid, of which about 80% of each acid is esterified, purchased from ISPA Alginates, LadyburnWorks, Girvan, Ayrshire, ScotlandKA269JN, UnitedKingdom.

Embodiment 2

[0039]

[0040] Description: ◆, This propylene glycol alginate contains 80% guluronicacid and 20% mannuronic acid, of which about 50% of each acid is esterified.

Embodiment 3

[0042]

[0043] Description: ▲, This propylene glycol alginate contains 20% guluronic acid and 80% mannuronic acid, of which about 70% of each acid is esterified.

[0044] Preparation:

[0045] Dispersions of the above samples were prepared in stainless steel vessels equipped with stirrers. Add carbomer (934P) into water and stir vigorously to form a uniform dispersion in water, then add the main ingredient slowly and make it evenly dispersed, then add sorbitol, tragacanth gum, propylene glycol alginate and Make it evenly dispersed, then add glycerin, sucrose ester and triethanolamine, mix well, adjust the pH value to 3.5-4.2 with sodium acetate or acetic acid, and finally add water to a sufficient amount (100%), stir until a uniform dispersion is obtained System (the above process can be heated to 50-80 ℃ if necessary).

[0046] Comparative example preparation method:

[0047] The component Kelcoloid S in the above-mentioned Example 1 was removed, and the others were ke...

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PUM

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Abstract

The invention discloses a sprayable metronidazole gel composition. The composition comprises metronidazole, water, a water-miscible solvent, carboxymethylcellulose, gamma-type carrageen glycan and 2000-20000 parts of PEG1 (polyethylene glycol 1). The gel composition is high in physical stability, high in salt-resistant capacity and convenient to use.

Description

technical field [0001] The present invention relates to a lotion with improved properties. Specifically, it relates to a lotion of metronidazole chlorhexidine with improved properties. Background technique [0002] Metronidazole and chlorhexidine can be used as a local external drug for various vaginitis caused by bacteria and trichomonas, and its lotion is commercially available. Its main components are as follows: every milliliter of this product contains 1.2 milligrams of chlorhexidine gluconate and 0.2 milligrams of metronidazole. The excipients are polysorbate-80 and ethanol. [0003] The above-mentioned lotion uses ethanol as a solvent, but the use of alcohols may damage the user's mucous membrane or skin and cause certain irritation, because the degreasing performance of alcohols will cause the user's mucous membrane or skin to form chapped and ruptured. Damaged mucous membranes or skin are more susceptible to microbial infection because pathogenic microbes, by res...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4164A61K9/08A61K47/36A61K47/32A61K47/26A61K47/10A61P15/02A61P31/04A61P33/02A61K31/155
Inventor 付劼张新明尤斌汪亚萍
Owner JIANGSU SEMPOLL PHARMA
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