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Chinese medicinal extract with anti-depression effect and preparation method and application thereof

An extract and anti-depressant technology, applied in the field of drug research and development, can solve the problems of no combination of anti-depressant drugs and no research reports on depressive diseases

Active Publication Date: 2014-08-13
石任兵 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no related reports on the purification and preparation of antidepressant drug substance combinations from Chai Jinfang, and there are no related research reports on the composition in the treatment of depression

Method used

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  • Chinese medicinal extract with anti-depression effect and preparation method and application thereof
  • Chinese medicinal extract with anti-depression effect and preparation method and application thereof
  • Chinese medicinal extract with anti-depression effect and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Embodiment 1: Capsules

[0059] Bupleurum 100g Turmeric 100g

[0060] Peilan 100g Shouwu 150g

[0061] Cinnamon 15g

[0062] According to the above ratio, take 1 kg of decoction pieces of the raw material drug, steam distill the other decoction pieces except Shouwu, and extract with 9 times water for 5 hours. After the medicinal materials are combined, reflux extraction with 70% ethanol for 2 times, each time for 1.5 hours; the obtained extract is dispersed and dissolved in water, so that the concentration of the aqueous solution is 0.01-0.1g / mL, preferably the concentration of the aqueous solution is 0.02-0.025g / mL; (with According to the amount of raw medicinal materials, the concentration of phenols is 0.7546 mg / ml, and the concentration of terpenes is 0.2012 mg / ml).

[0063] Through DM-130 macroporous adsorption resin, the adsorption flow rate is 2BV / h, the resin column diameter-to-height ratio is 1:6, the concentration of the sample solution is 0.02-0.025g / mL, a...

Embodiment 2

[0075] Embodiment 2: tablet

[0076] Bupleurum 100g Turmeric 80g

[0077] Peilan 100g Shouwu 100g

[0078] Cinnamon 10g

[0079] According to the above ratio, take 1 kg of decoction pieces of the raw material medicine, steam distill the other decoction pieces except Shouwu, and extract with 7 times water for 4 hours. After the medicinal materials are combined, reflux extraction with 70% ethanol for 3 times, each time for 1.5 hours; the obtained extract is dispersed and dissolved in water, so that the concentration of the aqueous solution is 0.01-0.1g / mL, preferably the concentration of the aqueous solution is 0.02-0.025g / mL; (with According to the amount of raw medicinal materials, the concentration of phenols is 0.7546 mg / ml, and the concentration of terpenes is 0.2012 mg / ml).

[0080] Through DM-130 macroporous adsorption resin, the adsorption flow rate is 2BV / h, the resin column diameter-to-height ratio is 1:6, the concentration of the sample solution is 0.02-0.025g / mL, ...

Embodiment 3

[0092] Embodiment 3: pill

[0093] Bupleurum 80g Turmeric 80g

[0094] Peilan 100g Shouwu 150g

[0095] Cinnamon 15g

[0096] According to the above ratio, take 1 kg of decoction pieces of the raw material medicine, steam distill the other decoction pieces except Shouwu, and extract with 5 times water for 3 hours. After the medicinal materials are combined, reflux extraction with 50% ethanol twice, each time for 2 hours; the obtained extract is dispersed and dissolved in water, so that the concentration of the aqueous solution is 0.01-0.1g / mL, preferably the concentration of the aqueous solution is 0.02-0.025g / mL; (with According to the amount of raw medicinal materials, the concentration of phenols is 0.7546 mg / ml, and the concentration of terpenes is 0.2012 mg / ml).

[0097] Through DM-130 macroporous adsorption resin, the adsorption flow rate is 3BV / h, the diameter-to-height ratio of the resin column is 1:8, the concentration of the sample solution is 0.02-0.025g / mL, and ...

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Abstract

The invention aims to provide a Chinese medicinal extract with an anti-depression effect and a preparation method and application thereof. The Chinese medicinal composition is screened from Chinese thorowax root-turmeric root-tuber prescription medicaments based on an anti-depression medicament system, and phenol components and terpene components in a Chinese thorowax root-turmeric root-tuber prescription are obtained by means of steam distillation, ethanol extraction and porous adsorption resin purification enrichment. As proved by a pharmacological experiment, the medicinal composition can be used for improving the depressive behavior of a model mouse, shortening the standing time of the mouse and restraining the body temperature drop caused by reserpine, thereby preventing and treating depression.

Description

technical field [0001] The invention belongs to the field of drug research and development, and relates to a drug substance, in particular to a drug substance with antidepressant activity and a preparation method thereof. Background technique [0002] Depression, also known as depressive disorder, is the main type of mood disorder with significant and persistent low mood as the main clinical feature. Traditional Chinese medicine believes that depression syndromes are mostly caused by emotional discomfort and stagnation of qi, such as depression, restlessness, chest fullness, hypochondrium pain, or irritability, or foreign body obstruction in the pharynx. as the main symptom. "Suwen Liuyuanzhengji Dalun" said: "If the depression is severe, what can be done to cure it? The wood Yuda, the fire Yufa, the soil Yu seizes, the gold Yu vents, and the water Yu breaks." At present, Western medicine treats The exact pathophysiological mechanism of depression is still not very clear, ...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A23L1/30A23L2/52A23L2/44A61P25/24
Inventor 石任兵王永炎韩珂卿彭平姜艳艳张硕峰畅洪昇潘婷
Owner 石任兵
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