Pharmaceutical composition containing 4-hydroxide radical-2-oxo-1-pyrrolidine acetamide and application thereof

Abstract

The invention discloses a pharmaceutical composition containing 4-hydroxide radical-2-oxo-1-pyrrolidine acetamide and the vitamin E and application of the pharmaceutical composition. The pharmaceutical composition containing 4-hydroxide radical-2-oxo-1-pyrrolidine acetamide and the vitamin E has a synergistic effect in the treatment process of neuromotor dysfunction and impaired memory dysfunction caused by vascular dementia and senile dementia, wherein the vitamin E can remarkably improve the treatment effect of oxiracetam. Accordingly, the effective dose of oxiracetam is reduced, the dosage is reduced, and adverse reaction is reduced after the pharmaceutical composition is applied for a long time. In this way, the pharmaceutical composition can more effectively treat intellectual disability of a dementia patient, the treatment effect can be achieved through the small dosage, and therefore the pharmaceutical composition is suitable for clinical use.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, in particular to a pharmaceutical composition containing 4-hydroxy-2-oxo-1-pyrrolidineacetamide and its application. Background technique [0002] Dementia is an acquired intelligence impairment syndrome with cognitive impairment as the core symptom. Cognitive impairment may involve functions such as memory, learning, orientation, comprehension, judgment, calculation, language, and visual space. The degree of intellectual impairment is sufficient Interference with activities of daily living or socio-occupational functioning. Dementia includes degenerative diseases and non-degenerative diseases, the former includes Alzheimer's disease (Alzheimer, AD) and dementia with Lewy bodies, and the latter includes vascular dementia (VD). AD, also known as senile dementia, is a neurological disease with memory and cognitive dysfunction as the main clinical manifestation and progressive a...

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