A kind of preparation method of monodisperse nano-starch microspheres with controllable particle size

A nano-starch, monodisperse technology, which is applied in the direction of non-active ingredient medical preparations, powder delivery, pharmaceutical formulations, etc., can solve the problems of unreachable, large size, and inability to control the particle size of microspheres, and achieve good application effects , Uniform size, good targeting effect

Inactive Publication Date: 2016-06-29
XIHUA UNIV
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Problems solved by technology

[0008] The existing starch microspheres mainly focus on the control of cross-linking agent, cross-linking density, and targeting during the preparation of microspheres. Although there are also reports on nano-microspheres, they are often large in size (hundreds of nanometers, which cannot reach Some special lesions), and the particle size of the microspheres cannot be adjusted, let alone monodisperse distribution

Method used

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  • A kind of preparation method of monodisperse nano-starch microspheres with controllable particle size
  • A kind of preparation method of monodisperse nano-starch microspheres with controllable particle size

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Experimental program
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Effect test

Embodiment 1

[0039] Embodiment 1: 150g soluble starch is dissolved in 1350g distilled water, is mixed with the starch solution that concentration is 10%. 600 g of water-soluble surfactant Tween20 and 6.1 g of inorganic salt NaCl were added to the solution, and the pH was adjusted to 9-10 with NaOH solution to obtain an aqueous phase. In addition, 1600g of oil-soluble surfactant Span80 and 53g of co-surfactant n-propanol were added to 4000g of organic solvent kerosene to obtain an oil phase. The oil phase and the water phase were mixed, mechanically stirred evenly, and left to stand for 2 hours to obtain a water-in-oil microemulsion.

[0040] Add the above-mentioned water-in-oil starch microemulsion into a 10000ml four-necked flask, stir mechanically (rotating speed 400rpm), pass nitrogen protection (gas flow rate is 10ml / min), add 32g crosslinking agent N,N-methylenebis Acrylamide, 5.6g water-soluble initiator ammonium persulfate, heat up to 45°C, keep warm at this temperature for 5h to c...

Embodiment 2

[0041] Embodiment 2: 100g of soluble starch was dissolved in 700g of distilled water to prepare a starch solution with a concentration of 12.5%. 225g of water-soluble surfactant Tween80 and 2.2g of inorganic salt KCl were added to the solution, and the pH was adjusted to 9-10 with NaOH solution to obtain an aqueous phase. Add 750g oil-soluble surfactant Span60 and 35g co-surfactant n-butanol to 3000g organic solvent kerosene in addition to obtain an oil phase. The oil phase and the water phase were mixed, mechanically stirred evenly, and left to stand for 1.5 hours to obtain a water-in-oil microemulsion.

[0042] Add the above-mentioned water-in-oil starch microemulsion into a 5000ml four-neck flask, stir mechanically (rotating speed 400rpm), pass nitrogen protection (gas flow rate is 10ml / min), add 18g crosslinking agent N,N-methylenebis Acrylamide, 3.5g water-soluble initiator cerium ammonium nitrate, heated up to 55°C, kept at this temperature for 4h to carry out cross-lin...

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Abstract

The invention aims to provide a method of controlling the grain size of starch microspheres so as to further prepare monodisperse nano starch microspheres in different grain sizes. The technical scheme provided by the invention is as follows: the preparation method comprises the following steps: preparing a starch solution; adding a water soluble surfactant and inorganic salt into the starch solution to obtain a water phase matter; adding an oil soluble surfactant and a co-surfactant into an organic solvent to obtain an oil phase matter; and mixing the water phase matter with the oil phase matter to obtain a water in oil starch microemulsion, cross-linking and solidifying, collecting precipitates, and washing and drying the precipitates to obtain white-to-yellowish powder which is the monodisperse nano starch microspheres. According to the preparation method provided by the invention, the grain size of the starch microspheres can be precisely controlled within a certain range (20-200nm) through selection of reaction raw materials and control of technical conditions, and the grain size is distributed in a monodisperse mode. The starch microspheres can be used as a carrier of a medicine, has better targeting and is oriented to a special organ or focus part.

Description

technical field [0001] The invention belongs to the fields of modification of natural polymer materials and medicinal polymer materials. The invention relates to a method for preparing nanoscale starch microspheres by using starch as a main raw material through inverse suspension microemulsion polymerization. The shape of starch microspheres is approximately spherical, the particle size distribution is concentrated, and it is approximately monodisperse; the surface of the microspheres is rough and has a certain degree of adsorption to fluids. It can be used as an immobilization material for fluids, especially as a carrier for drugs. Background technique [0002] Starch microspheres are cross-linked cross-linked particles with spherical or nearly spherical appearance and particle sizes ranging from nanometers to millimeters, which are prepared by grafting and crosslinking modification reactions with crosslinking agents and hydroxyl groups in starch molecules under certain con...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F251/00C08F2/32A61K9/14A61K47/36
Inventor 马素德闵忠华张勤勇袁乐
Owner XIHUA UNIV
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