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Anhydrous lactose preparation technology and apparatus thereof

An anhydrous lactose and preparation technology technology, applied in the production of sugar, lactose production, sugar production and other directions, can solve the problem that the production process of anhydrous lactose is not very perfect, is not conducive to the development of anhydrous lactose industry chain, and increases the use of anhydrous lactose. Cost and other issues, to achieve the effect of good product quality, good quality and high efficiency

Inactive Publication Date: 2014-08-27
江苏道宁药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Anhydrous lactose can turn into monohydrate lactose at a relative humidity of 70%. Anhydrous lactose contains about 1% water and 0.1-0.2% of adsorbed water. It is not very perfect and the yield is low. The anhydrous lactose required in the domestic market is all imported, which not only increases the cost of anhydrous lactose, but also is not conducive to the development of the anhydrous lactose industry chain. Therefore, the development of anhydrous lactose Research urgently needs to be addressed

Method used

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  • Anhydrous lactose preparation technology and apparatus thereof
  • Anhydrous lactose preparation technology and apparatus thereof
  • Anhydrous lactose preparation technology and apparatus thereof

Examples

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Effect test

Embodiment 1

[0030] A kind of preparation technology of anhydrous lactose, described preparation technology comprises the following steps:

[0031] (1) Put pharmaceutical grade lactose monohydrate and pure water into the dissolution tank according to the mass ratio of 1:0.4, heat with steam until the lactose in the solution is completely dissolved, the solution is clear and transparent, and keep the solution temperature at 90-98°C;

[0032] (2) Spray the solution in step (1) evenly on the surface of the drum scraper dryer through the spraying device, control the temperature on the surface of the drum scraper dryer to 120-130°C, and control the speed of the drum to 5-10 rpm / min.

Embodiment 2

[0034] A kind of preparation technology of anhydrous lactose, described preparation technology comprises the following steps:

[0035] (1) Put pharmaceutical grade lactose monohydrate and pure water into the dissolving tank according to the mass ratio of 1:0.5, heat with steam until the lactose in the solution is completely dissolved, the solution is clear and transparent, and the temperature of the solution is kept at 98-102°C;

[0036] (2) Spray the solution in step (1) evenly on the surface of the drum scraper dryer through the spraying device, control the temperature on the surface of the drum scraper dryer at 130-140°C, and control the speed of the drum at 10-15 Turn / min, so as to produce anhydrous lactose.

Embodiment 3

[0038] A kind of preparation technology of anhydrous lactose, described preparation technology comprises the following steps:

[0039] (1) Put lactose and pure water into the dissolution tank according to the mass ratio of 1:0.6, heat with steam until the lactose in the solution is completely dissolved, the solution is clear and transparent, and the temperature of the solution is controlled at 98-102°C;

[0040] (2) Spray the solution in step (1) evenly on the drum surface of the drum scraper dryer through the spraying device. During the spraying process, the temperature of the solution is controlled to be 98-102°C, and the temperature of the drum surface is controlled to be 130-140°C , and control the rotating speed of the drum to be 10-15 rpm to obtain the required anhydrous lactose.

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Abstract

The invention relates to the lactose production field, and especially relates to an anhydrous lactose preparation technology and an apparatus thereof. The preparation technology comprises the following steps: 1, adding lactose and pure water into a dissolving tank according to a mass ratio of 1:0.4-0.8, and carrying out steam heating until lactose is completely dissolved in order to obtain a clarified and transparent solution; and 2, uniformly sprinkling the surface of the roller of a roller scraper plate drying machine with the solution obtained in step 1 through a spraying device at a temperature of the surface of the roller of 120-160DEG C under a rotating speed of the roller of 5-20rpm in order to obtain anhydrous lactose. The anhydrous lactose preparation technology has the advantages of simple operation, automatic adjustment of the operating temperature and rotating speed in the preparation number, accurate control and automatic adjustment of the spraying speed; and by controlling the temperature of the lactose solution in a range of 90-105DEG C and adjusting the rotating speed and the drying temperature, the anhydrous lactose yield can reach above 95%, the quality is good, the product drying weight loss can be controlled within 0.5%, the moisture (Karl Fischer) is controlled within 1.0%, and the technology and the apparatus fill the gap in Chinese anhydrous lactose production.

Description

technical field [0001] The invention relates to the field of lactose production, in particular to a process for preparing anhydrous lactose and equipment thereof. Background technique [0002] Lactose is a natural disaccharide present in most mammalian milk consisting of galactose and sucrose. Lactose exists in two anomeric forms, α and β, monohydrate and anhydrate, respectively. α-lactose is produced by crystallization of a supersaturated solution below 93.5°C, while β-lactose is produced above this temperature. [0003] Anhydrous Lactose USP / NF, BP: Anhydrous lactose widely used in direct compression, which can obtain superior tablet shape strength, and because anhydrous lactose has higher inherent solubility than monohydrate lactose. It improves the stability and dispersibility of moisture-sensitive active ingredients in pharmaceutical products. The filler used for direct compression, if the tablet compressed by direct compression needs to be crushed and reworked, it w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C13K5/00
Inventor 张志彬魏利
Owner 江苏道宁药业有限公司