The invention provides an anti-
solvent fluid
mechanics control device and method for flower-shaped porous
lactose recrystallization equipment, and the device comprises a reaction kettle, a first stirrer, a second stirrer, a flow guide member, a
nozzle unit, a multi-zone sensor and a dynamic controller, the flow guide member divides the interior of the reaction kettle into a low-shear growth zone and a high-shear
mixing zone; the
nozzle unit comprises at least one first
nozzle, a second nozzle and a third nozzle; the multi-zone sensor comprises a PVM probe, an FBRM probe and a turbidimeter; when the reaction kettle runs, injecting a
lactose saturated solution into the low-shear growth area, starting the first nozzle to add an anti-
solvent in a dispersion mode, starting a
pulse mode of the second nozzle when the PVM probe detects that the
petal profile ratio reaches a preset value, and increasing the flow of the third nozzle when the FBRM probe detects that the growth rate is lower than the preset value. According to the invention, the problem of unstable form of flower type
lactose crystal is solved mainly through fluid
mechanics partitioning, multi-nozzle cooperation and
dynamic control.