Long-acting growth hormone and methods of producing same

A growth hormone and hormone technology, applied in the fields of erythropoietin, chemical instruments and methods, growth factors/inducing factors, etc.
CN104010650AInactive Publication Date: 2014-08-27OPKO BIOLOGICS
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
OPKO BIOLOGICS
Publication Date
2014-08-27
Estimated Expiration
Not applicable · inactive patent

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Abstract

Use of a growth hormone protein and polynucleotides encoding the same comprising an amino-terminal carboxy-terminal peptide (CTP) of chorionic gonadotrophin and two carboxy-terminal chorionic gonadotrophin CTPs attached to the growth hormone in methods of inducing weight loss or body fat reduction, methods of increasing insulin-like growth factor (IGF-1) levels, and methods of reducing the dosing frequency of a growth hormone in a human subject are disclosed. Pharmaceutical compositions comprising the growth hormone and polynucleotides encoding the growth hormone of the invention and methods of using same are also disclosed.
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Description

[0001] References to related applications

[0002] This application claims priority to U.S. Application Serial No. US 13 / 195,931, filed August 2, 2011, which is a continuation-in-part of U.S. Patent Application Serial No. US 12 / 509,188, filed July 24, 2009, which US 12 / 509,188 is a continuation of U.S. Patent Application Serial No. US12 / 476,916, filed June 2, 2009, which is a continuation of U.S. Patent Application Serial No. US12 / 401,746, filed March 11, 2009, which US12 / 401,746 is a continuation of US Patent Application Serial No. US 11 / 700,911, filed February 1, 2007, which claims the benefit of US Provisional Application Serial No. US 60 / 764,761, filed February 3, 2006. All of these applications are hereby incorporated by reference in their entirety. technical field

[0003] The present invention discloses growth hormone protein and the polynucleotide encoding the growth hormone protein in the method of inducing weight loss or body fat loss in human subjects, in the meth...

Claims

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