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Pharmaceutical composition containing desloratadine and dimemorfan phosphate

A technology of dimethylorphane phosphate and desloratadine, which is applied in the field of medicine to achieve the effect of reducing adverse reactions, low toxicity, and no side effects of constipation

Inactive Publication Date: 2014-09-17
HEFEI IND PHARMA INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

More preferably 5:10:200

Method used

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  • Pharmaceutical composition containing desloratadine and dimemorfan phosphate
  • Pharmaceutical composition containing desloratadine and dimemorfan phosphate
  • Pharmaceutical composition containing desloratadine and dimemorfan phosphate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Desloratadine + Dimethorphan Phosphate + Acetaminophen Granules (according to 1000 bags)

[0044] components

Dosage

Desloratadine

5.0g

Dimethyphane Phosphate

10.0g

Acetaminophen

200.0g

lactose

189.0g

aspartame

20.0g

Carmine

0.02g

Magnesium stearate

2.0g

essence

4.0g

[0045] Preparation:

[0046] Pass desloratadine, dimethylmorphan, acetaminophen, lactose, and aspartame through 80-mesh sieve respectively, mix well, dissolve carmine in water, make soft material, granulate with 20-mesh sieve, Dried, sieved with 18 meshes, added essence and magnesium stearate, mixed evenly, and divided into bags.

Embodiment 2

[0048] Desloratadine + Dimethorphan Phosphate + Paracetamol Tablets (Based on 1000 tablets)

[0049] components

Dosage

Desloratadine

10.0g

Dimethyphane Phosphate

10.0g

Acetaminophen

200.0g

[0050] microcrystalline cellulose

189.0g

aspartame

20.0g

Carmine

0.02g

Magnesium stearate

1.0g

essence

4.0g

[0051] Preparation:

[0052] Pass desloratadine, dimethylmorphan, acetaminophen, microcrystalline cellulose, and aspartame through 80-mesh sieve respectively, mix well, dissolve carmine in water, make soft material, 20-mesh sieve Granulate, dry, and sieve through a 18-mesh sieve, add essence and magnesium stearate, mix well, and press into tablets.

Embodiment 3

[0054] Desloratadine + Dimethorphin Phosphate + Acetaminophen Solution (according to 1000 bottles)

[0055] components

Dosage

Desloratadine

20.0g

Dimethyphane Phosphate

30.0g

Acetaminophen

200.0g

sodium benzoate

3.0g

aspartame

20.0g

sodium bisulfite

2.0g

essence

4.0g

water

10000ml

[0056] Preparation:

[0057] Dissolve desloratadine, dimethylorphane phosphate, and acetaminophen in an appropriate amount of water, heat and stir to dissolve, add sodium benzoate, aspartame, sodium bisulfite and essence, filter and add water to the prescribed amount, Stir well and distribute.

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PUM

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Abstract

The invention relates to the field of medicines and in particular relates to a compound pharmaceutical composition containing desloratadine, dimemorfan phosphate and acetaminophen. The pharmacodynamic test proves that the three components are combined to have an anti-influenza synergistic effect, and the pharmaceutical composition can be used for clinically treating cold.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound pharmaceutical composition containing desloratadine, dimethylmorphan phosphate and acetaminophen and a preparation method thereof. Background technique [0002] A common cold is a frequently-occurring disease caused by respiratory tract infection. At the beginning, there is dry throat, itchy throat or burning sensation. At the same time or a few hours after the onset, there may be sneezing, nasal congestion, and watery nasal discharge, which may be accompanied by sore throat. Inflammation can cause hearing loss, and tearing, dull taste, poor breathing, hoarseness, and a small amount of coughing may also occur. Generally, there is no fever and systemic symptoms, or only low-grade fever, malaise, mild chills and headache. Due to the complexity of the pathogenesis of colds, generally symptomatic treatment is mainly used to relieve various discomfort symptoms caused by colds. [...

Claims

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Application Information

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IPC IPC(8): A61K31/485A61P11/00A61P29/00A61P11/14A61K31/4545A61K31/167
Inventor 刘为中何广卫陈娟储昭兴
Owner HEFEI IND PHARMA INST
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