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Gas phase needle maintenance method for high-viscosity or high-freezing point substances

A high freezing point, high viscosity technology, applied in the field of chemical maintenance, can solve problems such as damage to the injection needle, no maintenance method, etc., to save resources, save experimental costs, and increase experimental accuracy.

Inactive Publication Date: 2014-09-17
江苏德峰药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the existing laboratory, cleaning or maintenance may only be thought of when it is temporarily used, and there is no systematic maintenance method. Therefore, it is easy for workers in the chemical field to study a gas phase needle maintenance method for a substance with high viscosity or high freezing point. Neglected problem that may lead to damage to the syringe

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] The experimental sample is 1-bromo-2-butyne, and the low-viscosity solvent is n-hexane, which not only reduces the viscosity of the tested substance, but also avoids the solvent from reacting with the tested substance and causing interference in the chromatogram.

[0019] First take out the sampling needle, use the automatic cleaning device to clean it with low-viscosity solvent 5 times before sampling, then use the sampling needle to inject the sample, and then immediately after the test is completed, use the low-viscosity solvent to clean it 10 times and place it properly to prevent the needle from being trapped Due to the solidification phenomenon of the residual test substance after the solvent volatilizes, it is easy to break or bend the needle piston at one time when it is used next time, and finally carry out regular inspection and cleaning steps. Generally, when the frequency of use is high, it will be 1-2 days, and the general use will be 3 days. - Check once ev...

Embodiment 2

[0023] The experimental sample is di-tert-butyl dicarbonate, and the low-viscosity solvent is n-heptane. The choice of low-viscosity solvent not only reduces the viscosity of the test substance, but also avoids the reaction between the solvent and the test substance and interference in the chromatogram.

[0024] First take out the sampling needle, use the automatic cleaning device to clean it with low-viscosity solvent 6 times before sampling, then use the sampling needle to inject the sample, and then immediately after the test is completed, use the low-viscosity solvent to clean it for 20 times and place it properly to prevent the needle from being trapped Due to the solidification phenomenon of the residual test substance after the solvent volatilizes, it is easy to break or bend the needle piston at one time when it is used next time, and finally carry out regular inspection and cleaning steps. Generally, when the frequency of use is high, it will be 1-2 days, and the genera...

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Abstract

The invention discloses a gas phase needle maintenance method for high-viscosity or high-freezing point substances. The method comprises the following four steps: 1, selecting a low-viscosity solvent as a solvent for gas chromatographic detection; 2, taking out a sample introduction needle and cleaning the sample introduction needle with the low-viscosity solvent 5 to 8 times by using an automatic cleaning device before sample introduction; 3, cleaning the sample introduction needle with the low-viscosity solvent more than 10 times immediately after completion of sample introduction; and 4, regularly detecting and cleaning the sample introduction needle in a period from completion of usage of the sample introduction needle to next-time usage of the sample introduction needle. The gas phase needle maintenance method for high-viscosity or high-freezing point substances provides cleaning steps and cleaning pace for gas phase needles from all the aspects, can realize effective, regular and real-time cleaning and maintenance of gas phase needles at regular intervals, effectively improves the usage efficiency of gas phase needles, enhances experimental accuracy, effectively saves experimental time, prolongs the service life gas phase needles and saves experimental cost.

Description

technical field [0001] The invention relates to a method for maintaining a gas phase needle of a substance with a high viscosity or a high freezing point, and belongs to the field of chemical maintenance. Background technique [0002] The gas phase autosampler is a very critical component in the gas phase, and it is also the most frequently used component, which is related to the accuracy and precision of the test. Good usage habits and maintenance methods can effectively ensure stable long-term testing. Many problems are often encountered during the testing process. [0003] It is also a liquid substance, when the substance with high viscosity or high freezing point (0-25°C) is quantitatively analyzed in the gas phase, it will encounter the residue of the substance in the sample needle, the amount of the substance entering the gas phase system analysis cannot be reproduced, and it will be used for a long time The plunger of the injection needle may become astringent or ev...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02B08B3/08B08B3/12
Inventor 王德峰钱建石飞
Owner 江苏德峰药业有限公司
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