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A kind of angelica wall breaking preparation

A technology of angelica and preparations, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, block delivery, etc., which can solve the problem of broken wall powders being oxidized due to moisture absorption, low stability, and easy drug efficacy. Loss and other problems, to achieve the effect of being easy to drink with warm water, improving the utilization rate, and easy to disintegrate and disperse

Active Publication Date: 2018-08-21
ZHONGSHAN ZHONGZHI PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the defects in the prior art that the broken wall powder is easy to absorb moisture and be oxidized, the stability is not high, and the drug effect is easily lost, and a kind of angelica broken wall preparation is provided.

Method used

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  • A kind of angelica wall breaking preparation
  • A kind of angelica wall breaking preparation
  • A kind of angelica wall breaking preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Take Angelica sinensis medicinal material, coarsely pulverize it into a coarse powder of about 100 meshes, and ultrafinely pulverize it into a powder with a particle size of about 24 μm in 90% of the ultrafine powder, add ethanol-water solution (the mass fraction of ethanol is 50% ) soft material by wet method, the ratio of solution to superfine powder is 0.44:1 (by weight), after mixing, pre-installed 10-mesh sieve, the extrusion speed is 50r / min, and the extrusion force is 1MPa to make wet granules , the wet granules were transposed into a hot air circulation oven, the drying temperature was set at 65°C, and dried for 3.0 hours until dry.

[0030]

[0031] Note: The full score is 10.

Embodiment 2

[0033] Take Angelica sinensis medicinal material, coarsely pulverize it into a coarse powder of about 100 meshes, and ultrafinely pulverize it into a powder with a particle size of about 35 μm in 90% of the ultrafine powder, add ethanol-water solution (the mass fraction of ethanol is 60%) ) soft material by wet method, the ratio of solution to superfine powder is 0.48:1 (by weight), after mixing, pre-installed 10-mesh sieve, the extrusion speed is 50r / min, and the extrusion force is 0.9MPa to make wet Granules, wet granules are transferred to a vacuum microwave drying oven, set the drying temperature to 45°C, and dried for 0.75h until dry.

[0034]

[0035] Note: The full score is 10.

Embodiment 3

[0037] Take Angelica sinensis medicinal material, coarsely pulverize it into a coarse powder of about 100 meshes, and ultrafinely pulverize it into a powder with a particle size of about 32 μm in 90% of the ultrafine powder, add ethanol-water solution (the mass fraction of ethanol is 95%) ) soft material by wet method, the ratio of solution to ultra-fine powder is 0.66:1 (by weight), after mixing, pre-installed 30 mesh sieve, the extrusion speed is 80r / min, and the extrusion force is 0.3MPa to make wet Granules, wet granules are transferred to a hot air circulation oven, set the drying temperature to 65°C, and dried for 2.5 hours to dryness.

[0038]

[0039] Note: The full score is 10.

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Abstract

The invention relates to the technical field of Chinese medicine preparations, and in particular relates to an angelica wall-broken preparation. The angelica wall-broken preparation is prepared as follows: crushing angelica into broken powder, then granulating by use of an ethanol-water wet method, extruding for forming at a certain speed and drying, and the prepared angelica wall-broken preparation is high in bioavailability, strong in stability, and good in disintegration.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, in particular to an angelica wall breaking preparation. Background technique [0002] Ultrafine pulverization technology is a new technology developed rapidly in recent years. Most of the active ingredients in Chinese herbal medicines are distributed in the cells. Conventional decoction pieces can only release part of the active ingredients, and the utilization rate of active ingredients is 10-30%. However, using the wall-breaking crushing technology, such as crushing Chinese herbal medicine pieces to 300 mesh About 86.7% of the cell wall breaking rate will increase the dissolution of the active ingredients in the medicinal materials, greatly enhance its efficacy, and the utilization rate of the active ingredients will be above 90%, so as to reduce the amount of medicinal materials used and protect the medicinal materials resources. The quality increases the efficacy. However, the cu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/10A61K36/232A61K9/16A61K125/00
Inventor 成金乐陈勇军徐吉银陈金梅梁燕玲
Owner ZHONGSHAN ZHONGZHI PHARMA GRP
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