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Persistent intestinal catarrh rat model for medium and long term nutrition evaluation and establishment method thereof

A technology for nutritional evaluation and establishment of methods, which is applied in the direction of medical formulas, organic active ingredients, and medical preparations containing active ingredients, etc. It can solve the problems that are not suitable for the overall effect evaluation of medium and long-term nutritional support, and achieve long damage cycle and prolong the course of disease , the effect of simple operation

Inactive Publication Date: 2014-10-01
SERICULTURE & AGRI FOOD RES INST GUANGDONG ACAD OF AGRI SCI
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  • Application Information

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Problems solved by technology

This model shows the typical pathogenic characteristics of intestinal mucositis caused by chemotherapy, and is mainly used to evaluate the therapeutic effect of chemical drugs or single nutrients that have significant effects in the short term, but it is not suitable for the overall effect evaluation of medium and long-term nutritional support

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  • Persistent intestinal catarrh rat model for medium and long term nutrition evaluation and establishment method thereof
  • Persistent intestinal catarrh rat model for medium and long term nutrition evaluation and establishment method thereof
  • Persistent intestinal catarrh rat model for medium and long term nutrition evaluation and establishment method thereof

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Embodiment Construction

[0040] The examples described here are only used to explain the present invention, and are not intended to limit the present invention.

[0041] SD rats, male, weighing (200±10) g, were exposed to light for 12 hours a day, and the room temperature was maintained at 22-25°C. During the whole process of adaptive feeding and modeling, all animals had free access to water and food. For MTX for injection, make up 10 mg / kg with normal saline before use. On day 0, SD rats were intraperitoneally injected with MTX 10 mg / kg. On the sixth day, MTX 10 mg / kg was injected intraperitoneally again. On the 12th day, the intestinal mucosal injury basically returned to normal.

[0042] In order to make the purpose, technical solution and advantages of the present invention clearer, the modeling method of the present invention is compared with the traditional one-time high-dose (20 mg / kg) injection MTX modeling method and other randomly selected small doses of MTX. MTX injection (first inject...

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Abstract

The invention discloses a persistent intestinal catarrh rat model for medium and long term nutrition evaluation and an establishment method thereof. According to the method, 10mg / kg of methotrexate (MTX) is injected to the rat enterocoelia twice, on 0 day and 6th day 6. The model can be used for better simulating the actual situation of intestinal mucosa injury caused by chemotherapy, is suitable for medium and long term nutrition supported integral effect evaluation, as well as studies on patho-physiologic change of intestinal mucosa injured body caused by chemotherapy.

Description

technical field [0001] The invention relates to the technical field of animal experimental models, in particular to a rat persistent intestinal mucositis model suitable for medium and long-term nutritional evaluation and a method for establishing the same. Background technique [0002] "Intestinal mucositis", also known as "intestinal mucosal barrier damage", is a common complication during chemotherapy for cancer patients. Chemotherapy drugs, especially high-dose chemotherapy drugs, can cause damage to the gastrointestinal tract, causing a series of gastrointestinal symptoms such as nausea, vomiting, diarrhea, loss of appetite, water-electrolyte and acid-base balance disorders, which seriously affect the patient's eating and prolong the hospital stay. Even affect the course of chemotherapy and disease prognosis. In order to evaluate the physiological and pathological changes in the body due to intestinal mucosal injury during chemotherapy, such as metabolism, nutrition, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519
Inventor 邓媛元张名位张瑞芬魏振承张雁唐小俊刘磊遆慧慧马永轩
Owner SERICULTURE & AGRI FOOD RES INST GUANGDONG ACAD OF AGRI SCI