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Compound of total salvianolic acids and sophoridine and preparation method thereof

A technology of total phenolic acid and sophoridine of salvia miltiorrhiza is applied in the field of preparation of traditional Chinese medicine complexes, which can solve the problems of not very strong activity, not very good stability, and great vascular irritation, so as to reduce impurities and improve antitumor activity. , reduce irritation effect

Inactive Publication Date: 2014-10-08
JIANGSU TIANSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although both have certain pharmacological activity, because they have strong acidity and alkalinity respectively, the stability is not very good, and there is also the problem of greater irritation of mucous membranes and blood vessels when used alone, and especially in anti-inflammatory drugs. In terms of tumors, the activity is not very strong when used alone

Method used

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  • Compound of total salvianolic acids and sophoridine and preparation method thereof

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Effect test

Embodiment 1

[0016] Preparation of the compound of salvianolic acid and sophoridine according to the present invention comprises the following steps:

[0017] (1) Dissolving the total phenolic acids of salvia miltiorrhiza: add 100ml of water to 100g of total phenolic acids of salvia miltiorrhiza, then heat to 70°C, the total phenolic acids of salvia miltiorrhiza are dissolved in water to form a solution of total phenolic acids of salvia miltiorrhiza;

[0018] (2) Preparation of the compound of salvianolic acid and sophoridine: add 40 g of sophoridine to the solution of salvianolic acid described in step (1), stir the reaction until the solution is clear, and then slowly add 800ml of ethanol was stirred to precipitate the compound of salvianolic acid and sophoridine, then filtered and dried at 50°C for 5 hours to obtain 104g of compound of salvianolic acid and sophoridine.

Embodiment 2

[0020] Preparation of the compound of salvianolic acid and sophoridine according to the present invention comprises the following steps:

[0021] (1) Dissolving the total phenolic acids of salvia miltiorrhiza: add 100ml of water to 200g of total phenolic acids of salvia miltiorrhiza, then heat to 40°C, the total phenolic acids of salvia miltiorrhiza are dissolved in water to form a solution of total phenolic acids of salvia miltiorrhiza;

[0022] (2) Preparation of the compound of salvianolic acid and sophoridine: add 10 g of sophoridine to the solution of salvianolic acid described in step (1), stir until the solution is clear, and then slowly add 500ml of methanol was stirred to separate out the complex of salvianolic acid and sophoridine, then filtered and dried at 80°C for 2 hours to obtain 182g of the complex of salvianolic acid and sophoridine.

Embodiment 3

[0024] Preparation of the compound of salvianolic acid and sophoridine according to the present invention comprises the following steps:

[0025] (1) Dissolving the total phenolic acids of salvia miltiorrhiza: add 100ml of water to 90g of total phenolic acids of salvia miltiorrhiza, then heat to 60°C, and dissolve the total phenolic acids of salvia miltiorrhiza in water to form a solution of total phenolic acids of salvia miltiorrhiza;

[0026] (2) Preparation of the compound of salvianolic acid and sophoridine: add 15 g of sophoridine to the solution of salvianolic acid described in step (1), stir until the solution is clear, and then slowly add 300ml of ethanol was stirred to separate out the complex of salvianolic acid and sophoridine, then filtered and dried at 60°C for 6 hours to obtain 102g of the complex of salvianolic acid and sophoridine.

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Abstract

The invention discloses a compound of total salvianolic acids and sophoridine and a preparation method thereof. The compound comprises total salvianolic acids and sophoridine in the mass ratio of (5-10):1. The preparation method comprises the following steps: (1) dissolving total salvianolic acids; and (2) merging the total salvianolic acids with sophoridine, and then precipitating, filtering and drying to obtain the compound of the total salvianolic acids and the sophoridine. The compound formed by the total salvianolic acids and the sophoridine disclosed by the invention is a neutral compound. Therefore, the stability is improved, the irritation is reduced, the synergistic effect is excellent, and the antitumor activity of the compound is improved.

Description

technical field [0001] The invention relates to a compound of salvia miltiorrhiza total phenolic acid and sophoridine and a preparation method thereof, and belongs to the technical field of preparation methods of traditional Chinese medicine compounds. Background technique [0002] Salvia miltiorrhiza is a class of chemical components present in Salvia miltiorrhiza, mainly composed of salvianolic acid A, salvianolic acid B, salvia miltiorrhiza, salvia miltiorrhiza The common feature of this kind of chemical composition is that it contains multiple phenolic hydroxyl groups in the molecular structure, showing strong acidity. Salvianolic acid has strong pharmacological activity, mainly used in cardiovascular and cerebrovascular, anti-oxidation, anti-tumor and other aspects. [0003] Sophoridine is an alkaloid component isolated and purified from the leguminous plant Sophora sophora, and it is a compound with strong alkalinity. Studies have shown that sophoridine can inhibit t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P35/00A61K31/4375
Inventor 杨永安朱海亮汤文建钟慧
Owner JIANGSU TIANSHENG PHARMA