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Liquid crystal midbody containing difluoro methyl ether bridged bond and synthesis method thereof

A technology of difluoromethyl ether and synthesis method, applied in chemical instruments and methods, ether preparation, preparation of organic compounds, etc., can solve the problems of ineffective production, low total yield, long reaction route, etc., and improve production efficiency , the effect of low production cost and high reaction yield

Inactive Publication Date: 2014-10-08
XIAN MODERN CHEM RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] 1) The reaction route is long and the total yield is low;
[0012] 2) For the preparation of homologues with the same molecular skeleton and different R substituents, a large number of repeated synthesis is required from scratch, which cannot be effectively produced

Method used

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  • Liquid crystal midbody containing difluoro methyl ether bridged bond and synthesis method thereof
  • Liquid crystal midbody containing difluoro methyl ether bridged bond and synthesis method thereof
  • Liquid crystal midbody containing difluoro methyl ether bridged bond and synthesis method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Preparation of 5-((4-bromo-2,6-difluorophenyl)difluoromethoxy)-1,3-difluoro-2-(2,2,2-trifluoroethoxy)benzene:

[0045] The specific structural formula is as follows:

[0046]

[0047] The preparation process is as follows:

[0048] (1) Add 177.1g (1mol) 3,4,5-trifluoronitrobenzene and 500mL DMF into the reaction flask, stir well, and cool to 0°C. Add 134.2 g (1.1 mol) sodium trifluoroethoxide in batches, and control the temperature not to exceed 20°C. After the addition was complete, the reaction was carried out at 20°C for 5 hours. After the reaction was completed, toluene was added for extraction, and washed with water until neutral. The organic phase was concentrated to dryness to obtain 247 g of oily liquid. The obtained oily liquid was purified by silica gel column using n-heptane as eluent to obtain 240 g of colorless oily liquid. GC content 99.5%, yield 93.3%.

[0049] (2) Add 240 g of the above-mentioned oily liquid and 500 mL of tetrahydrofuran into a ...

Embodiment 2～3

[0059] Using 2-fluoro-4-bromobenzoic acid and 4-bromobenzoic acid to replace 2,6-difluoro-4-bromobenzoic acid in the step (4) of Example 1 respectively, the same method was used to synthesize:

[0060]

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PUM

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Abstract

The invention discloses a liquid crystal midbody containing a difluoro methyl ether bridged bond and a synthesis method of the liquid crystal midbody. The structural formula (I) of the liquid crystal midbody is as shown in the specification. In the structural formula, L1 and L2 are H or F. The synthesis method comprises reaction steps as shown in the figures. The liquid crystal midbody containing the difluoro methyl ether bridged bond can be widely applied to preparation of a difluoro methyl ether bridged bond liquid crystal monomer.

Description

technical field [0001] The invention relates to a liquid crystal intermediate and a synthesis method thereof, in particular to a liquid crystal intermediate containing difluoromethyl ether bridges and a synthesis method thereof. Background technique [0002] Liquid crystal material is the key material of liquid crystal display, which plays an important role in improving various performances of liquid crystal display. Liquid crystal displays require liquid crystal materials to have good stability and a wide temperature range of the liquid crystal phase. In particular, the liquid crystal material is required to have a large dielectric anisotropy to reduce the driving voltage of the display and achieve the purpose of saving power; in addition, the liquid crystal material is also required to have a low viscosity, which can increase the response speed of the liquid crystal display. [0003] Difluoromethyl ether bridged liquid crystals containing difluoroethyleneoxy end groups ar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C41/01C07C43/225
CPCC07C41/01C07C41/26C07C201/12C07C213/02C07D339/08C07C43/225C07C205/37C07C217/84C07C43/23
Inventor 安忠维胡明刚李建李娟利车昭毅杨志杨晓哲莫玲超
Owner XIAN MODERN CHEM RES INST