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Preparation method of Tibetan medicine unique effervescent tablet

A unique and effervescent tablet technology, which is applied in pharmaceutical formulations, medical preparations containing active ingredients, drug delivery, etc., can solve the problems of pockmarked noodle product stability, long production cycle, and loss of active ingredients, and shorten production cycle, excellent placement stability, and increased stability

Active Publication Date: 2019-01-11
JIANGXI POZIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The drug extraction process is under severe conditions, and the active ingredients are easily lost; the preparation process is complicated, the production cycle is long, and the tablet is prone to such disadvantages as stretching, bursting, and pockmarking, and poor product stability.

Method used

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  • Preparation method of Tibetan medicine unique effervescent tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Preparation of Duyiwei extract: crush Duyiwei through a 40-mesh sieve, weigh 5 kg, soak in 60L of water as a solvent for 1.5 hours, then extract with an ultrasonic extractor at 35kHz, 60°C for 30min, and then filter to obtain a filtrate. The filter residue was then extracted with 50 L of water using an ultrasonic extractor at 35 kHz and 60° C. for 20 min, and filtered to obtain a secondary filtrate. The filter residue was extracted under the same conditions for the second time to obtain the third filtrate; the above three extracts were combined, concentrated under reduced pressure at 0.85Mpa at a vacuum degree of 60°C to an extract with a relative density of 1.20-1.30 (at 50°C); The extract was dried at a vacuum degree of 0.85Mpa at 60°C until the water content was less than 5.0%, and passed through an 80-mesh sieve to obtain 1228g of the extract. The content of n-butanol extract in the extract is 11.72%, the content of total flavonoids (calculated as rutin) is 11.68%, ...

Embodiment 2

[0030] Preparation of Duyiwei extract: crush Duyiwei through a 40-mesh sieve, weigh 10 kg, soak in 120L of water as a solvent for 2 hours, then extract with an ultrasonic extractor at 40kHz, 60°C for 40min, and then filter to obtain a filtrate. The filter residue was then extracted with 100 L of water using an ultrasonic extractor at 40 kHz and 60° C. for 30 min, and filtered to obtain a secondary filtrate. The filter residue was extracted under the same conditions for the second time to obtain the third filtrate; the above-mentioned three extractions were combined, and concentrated under reduced pressure at 0.85Mpa at a vacuum degree of 60°C to an extract with a relative density of 1.20-1.30 (at 50°C); The extract was dried at a vacuum degree of 0.855Mpa at 60°C until the water content was less than 5.0%, and passed through an 80-mesh sieve to obtain 2510g of the extract. The content of n-butanol extract in the extract is 11.95%, the content of total flavonoids (calculated as...

Embodiment 3

[0042] Preparation of Duyiwei extract: crush Duyiwei through 40 meshes, weigh 20 kg, soak in 240L water as solvent for 2 hours, then extract with an ultrasonic extractor at 40kHz, 60°C for 50min, and then filter to obtain a filtrate. The filter residue was then extracted with 200 L of water using an ultrasonic extractor at 40 kHz and 60° C. for 40 min, and filtered to obtain a secondary filtrate. The filter residue was extracted under the same conditions for the second time to obtain the third filtrate; the above three extracts were combined, concentrated under reduced pressure at 0.85Mpa at a vacuum degree of 60°C to an extract with a relative density of 1.20-1.30 (at 50°C); The extract was dried at a vacuum degree of 0.855Mpa at 60°C until the water content was less than 5.0%, and passed through an 80-mesh sieve to obtain 5110g of the extract. In the extract, the content of n-butanol extract is 11.69%, the content of total flavonoids (calculated as rutin) is 11.11%, and the ...

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Abstract

A preparation method of a preparation method of a Tibetan medicine Lamiophlomis rotata effervescent tablet belongs to the field of Chinese patent medicinal preparations. The method comprises the following steps: 1, preparing a Lamiophlomis rotata extract; 2, preparing an alkali source wrappage; 3, carrying out dry granulation; 4, tabletting; 5, examining; and 6, packaging. The effective components of the above medicinal material are extracted by adopting an ultrasonic extraction process, so energy saving, time saving and high extraction rate of the effective components are realized; an alkali source indispensable in the preparation is wrapped by PVP (polyvinylpyrrolidone) in advance, so the direct contact of an acid with an alkali in the preparation is avoided, the stability is increased, and it is in favor of solving a sticking problem during tabletting; and the contact time of the extract with the acid, the alkali, water and heat is maximally reduced, so the acceleration of interaction of the extract in the above prescription with the acid source and the alkali source is avoided, the material fluidity is improved, and the production period is shortened.

Description

technical field [0001] The invention belongs to the field of Chinese patent medicine preparations, and in particular relates to a method for preparing effervescent tablets of unique Tibetan medicine. Background technique [0002] Lamiophlomis rotata (Benth.) Kudo (Lamiophlomis rotata (Benth.) Kudo) belongs to the Lamiophlomis rotata genus. It is called "Daba" and "Dabuba" in Tibetan. Its leaves are rosette-shaped and stemless. The cymes are densely arranged in heads or spikes, and the corolla is lavender, purple or pinkish-brown. Distributed in Qinghai, Gansu, western Sichuan and northwestern Yunnan. Its roots, rhizomes or whole plants are used as medicine. The surface of the medicinal material is withered yellow or yellowish brown. It tastes bitter and flat in nature. It has the effects of promoting blood circulation, removing blood stasis, reducing swelling and relieving pain. It is an important Tibetan medicine that has been used for many years for folks to treat incisi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/46A61K36/53
Inventor 肖军平吴永忠伊文娟陈梁刘立鼎
Owner JIANGXI POZIN PHARMA
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