Method for improving immunogenicity of 13-valent pneumococcal polysaccharide-protein conjugate
A pneumococcal polysaccharide and immunogenicity technology, applied in the direction of carrier-binding antigen/hapten components, antibacterial drugs, drug combinations, etc., can solve problems such as poor immune effect, large variability of immunogenicity, and differences in immunogens
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[0031] The specific implementation method of the present invention is illustrated below, but not limited to the following examples.
[0032] The first step, preparation of carrier protein and pneumococcal polysaccharide
[0033] In order to illustrate the effectiveness of the present invention, two carrier proteins were prepared, namely the protein carrier OVApCRM197A containing OVAp and the protein carrier CRM197A not containing OVAp. Among them, the CRM197A protein carrier is used to synthesize the 13-valent pneumococcal polysaccharide-CRM197A conjugate sample for control.
[0034] 1. Design of amino acid sequence of CRM197A protein carrier and OVApCRM197A protein carrier
[0035] 1. Design of amino acid sequence of CRM197A protein carrier
[0036] Diphtheria toxin is expressed in Bacillus diphtheriae by β-phage with diphtheria toxin gene, and exists in the form of polypeptide in the bacterial cytoplasm, consisting of 560 amino acids with a molecular weight of 62,000 Dalto...
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