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Micro-fluidic chip and self-assembling method

A microfluidic chip and self-assembly technology, applied in the field of microfluidics, can solve the problems of consuming a large dispersed phase, consuming a long time, difficult to control particle dispersion and size, and achieving uniform particle morphology, easy manipulation, Easy-to-control effects

Active Publication Date: 2014-10-22
SOUTH CHINA NORMAL UNIVERSITY +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, these existing self-assembly methods have the following disadvantages: first, the particles used for self-assembly need to be prepared separately, and the dispersion and size of the particles are difficult to control due to the difference in the preparation method; secondly, since the particles are dispersed in a solvent (ie In the continuous phase), a large amount of dispersed phase is required for dispersion, and a large amount of dispersed phase is consumed. The particles in the dispersed phase are self-assembled through intermolecular forces, chemical potential changes, pH changes, etc., and this process consumes a lot of energy. It takes a long time and requires special experimental conditions and equipment support, which limits the wide range of applications of self-assembled materials in photonic crystals, acoustics, micro-manufacturing systems, drug release, sensing, etc.

Method used

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Embodiment 1

[0025] refer to figure 1 , a structural schematic diagram of a microfluidic chip in a preferred embodiment of the present invention, the liquid enters the first channel 1 and the second channel 2 respectively and then merges into the third channel 3, flows through the third channel and then enters the fourth channel 4 and connects with the fourth channel Several branch channels 5 communicated by the channel, the chip also includes side channels 6 communicated with the branch channels, the width of the third channel 3 is less than the width of the first channel 1, the second channel 2 and the fourth channel 4, the first channel 1 The second channel 2 is axisymmetrically distributed, the branch channel 5 and the side channel 6 are distributed axisymmetrically with the fourth channel 4, and the branch channel 5 is vertically connected to the fourth channel 4, the first channel 1 and the second channel 2 There are liquid inlets a and b respectively, and the fourth channel 4 and th...

Embodiment A

[0037] Phase A is hexadecane, in which 2.5wt% Span80 is added as a surfactant, and phase B is deionized water. Using a fluid pump, the two phases A and B are introduced into the first channel 1 and the second channel through the liquid inlets a and b respectively. In the second channel 2, when the flow rate of phase A is 40-100 μL / h, and the flow rate of phase B is 15-50 μL / h, the size of micro-droplets of phase B is 30-48 μm, which is a one-dimensional close-packed structure formed by self-assembly. When the flow rate of phase A is 100-400 μL / h, and the flow rate of phase B is 50-100 μL / h, the size of micro-droplets of phase B is 25-30 μm, and a two-dimensional close-packed structure is formed by self-assembly.

[0038] When the flow rate of phase A is 400-600 μL / h, and the flow rate of phase B is 100-200 μL / h, the size of micro-droplets of phase B is 20-30 μm, which is a three-dimensional close-packed structure formed by self-assembly.

Embodiment B

[0040] Phase A is hexadecane, add 2.5wt% Span80 as a surfactant, phase B is 6wt% N-isopropylacrylamide aqueous solution, and use a fluid pump to introduce the two phases A and B through the liquid inlets a and b respectively In the first channel 1 and the second channel 2, adjust the flow rate of phase A to 900-1200 μL / h, and the flow rate of phase B to 400-600 μL / h. The obtained micro-droplets of phase B have a size of 18-30 μm. stacked structure.

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Abstract

The invention discloses a micro-fluidic chip and a self-assembling method. The micro-fluidic chip comprises a first channel, a second channel, a third channel, a fourth channel and a plurality of branched chain channels, wherein liquid enters from the first channel and the second channel respectively and then is gathered at an intersection of the first channel, the second channel and the third channel; monodispersed micro-droplet particles are formed after the liquid is gathered by adjusting the flowing speed of fluid; the particles and the liquid are separated through the fourth channel by a branched chain structure, so that self-assembling of the particles in the fourth channel is realized. Due to adjustment of the flowing speed of the liquid and change of the sizes of the channels, the particles with different particle sizes can be obtained, and a single-layer / double-layer / multi-layer three-dimensional ordered compound self-assembled structure is realized. The self-assembling method can be used for self-assembling of the particles.

Description

technical field [0001] The invention relates to microfluidic technology, in particular to a microfluidic chip for self-assembly and a technique for realizing self-assembly of monodisperse particles by using the chip. Background technique [0002] Microfluidic technology, which appeared in the early 1980s, is an emerging field integrating engineering, physics, chemistry, biotechnology, and micro-manufacturing technology. Microfluidic technology effectively and accurately controls and manipulates microscale fluids, especially micron to submicron structures, on a chip of a few centimeters square, so microfluidic chips are the main platform for its realization. Using microfluidic technology, a large number of micro-droplets can be produced online in a few minutes or even less (speed up to 1Hz~10 4 Hz), the generated liquid beads can be adjusted in situ at the specified position, so as to achieve the purpose of self-assembly into an ordered structure. Therefore, this method can...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
Inventor 水玲玲王娟金名亮周国富
Owner SOUTH CHINA NORMAL UNIVERSITY
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