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Medicated leaven capsule for stomachache and preparation method thereof

A stomachache and capsule technology, applied in the field of Shenqu Weitong capsule and its preparation, can solve the problems of unsatisfactory curative effect, slow dissolution, low curative effect and the like

Inactive Publication Date: 2014-10-29
HEILONGJIANG JIANGHENG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the composition and process of Shenqu Weitong Capsules on the market, the curative effect is not ideal. The preparation is prepared by traditional technology, which has the disadvantages of slow dissolution and low curative effect.

Method used

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  • Medicated leaven capsule for stomachache and preparation method thereof
  • Medicated leaven capsule for stomachache and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Take 100g of Clematis clematis, 280g of rhubarb, 100g of belladonna slices, 10g of ginger, grind them into 60-mesh coarse powder, and extract them with carbon dioxide supercritical extraction method, the extraction pressure is 30Mpa, the extraction temperature is 30°C, the separator pressure is 10Mpa, and the separator temperature is 50°C. ℃, the separation time is 2 hours, and the flow rate of carbon dioxide is 40L per hour to obtain the extract; take the extract and dry it under reduced pressure at 60°C to obtain a dry paste; add 150g of calcium sulfate to the dry paste, and use a high-energy nano-impact mill to pulverize it into a particle size of 200-300nm Mixed dry paste powder; take mixed dry paste powder, aspartame 45g, cross-linked polyvinylpyrrolidone 45g, mix well, wet granulate with 50% ethanol, dry at 60°C, add sodium carboxymethyl starch 7g, stearin Magnesium acid 1g, whole grain, packed into capsules, made into 1000 capsules.

specific Embodiment 2

[0023] Take 100g of Clematis clematis, 280g of rhubarb, 100g of belladonna slices, 10g of ginger, grind them into 60-mesh coarse powder, and use carbon dioxide supercritical extraction method to extract, the extraction pressure is 40Mpa, the extraction temperature is 40°C, the separator pressure is 20Mpa, and the separator temperature is 60 ℃, the separation time is 4 hours, and the carbon dioxide flow rate is 50L per hour to obtain the extract; take the extract and dry it under reduced pressure at 80°C to obtain a dry paste; add 200g of calcium sulfate to the dry paste, and use a high-energy nano-impact mill to pulverize it into a particle size of 200-300nm Mixed dry paste powder; take mixed dry paste powder, aspartame 55g, cross-linked polyvinylpyrrolidone 55g, mix well, wet granulate with 70% ethanol, dry at 80°C, add sodium carboxymethyl starch 9g, stearin Magnesium acid 3g, whole grain, packed into capsules, made into 1000 capsules.

Embodiment 3

[0025] Take 100g of clematis, 280g of rhubarb, 100g of belladonna slices, 10g of ginger, grind them into 60-mesh coarse powder, and extract them with carbon dioxide supercritical extraction method, the extraction pressure is 35Mpa, the extraction temperature is 35°C, the separator pressure is 15Mpa, and the separator temperature is 55°C. ℃, the separation time is 3 hours, and the flow rate of carbon dioxide is 45L per hour to obtain the extract; take the extract and dry it under reduced pressure at 70°C to obtain a dry paste; add 175g of calcium sulfate to the dry paste, and use a high-energy nano-impact mill to pulverize it into a particle size of 200-300nm Mixed dry paste powder; take mixed dry paste powder, aspartame 50g, cross-linked polyvinylpyrrolidone 50g, mix well, wet granulate with 60% ethanol, dry at 70°C, add sodium carboxymethyl starch 8g, stearin Magnesium acid 2g, whole grain, packed into capsules, made into 1000 capsules.

[0026] The above examples illustrate ...

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Abstract

The invention discloses a medicated leaven capsule for a stomachache and a preparation method thereof. The preparation method of the medicated leaven capsule is characterized by comprising the following steps: taking 100g of radix clematidis, 280g of rheum officinale, 100g of belladonna tablet and 10g of fresh ginger; extracting the raw materials by adopting a supercritical carbon dioxide extraction method, drying the raw materials under reduced pressure, and crushing the raw materials into a nano dry paste by using a high-energy nano impact mill; adding a functional auxiliary material, and preparing into the euphorbia humifusa tablet for the stomachache. The disintegration time is obviously shortened, the curative effect is significantly superior to that of the commercially available euphorbia humifusa tablet for the stomachache, and a positive effect is obtained.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a Shenqu Weitong capsule and a preparation method thereof. Background technique [0002] Shenqu Weitong Capsule regulates qi and relieves pain, invigorates the spleen and eliminates food. It is used for hyperacidity, stomach pain, loss of appetite and indigestion. Due to the composition and process of Shenqu Weitong Capsules on the market, the curative effect is not satisfactory. The preparation is prepared by traditional technology, which has the disadvantages of slow dissolution and low curative effect. Contents of the invention [0003] In order to overcome the above disadvantages, the present invention provides a Shenqu Weitong Capsule with fast dissolution rate and high curative effect and a preparation method thereof. [0004] Invention embodiment is as follows: [0005] Take 100g of clematis, 280g of rhubarb, 100g of belladonna slices, 10g of ginger, grind...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/48A61P29/00A61P1/14A61P1/04
Inventor 朱文江
Owner HEILONGJIANG JIANGHENG PHARMA TECH CO LTD
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