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Absorbable orthopedic apparatus material having antibiosis and bone growth promotion functions, and preparation method thereof

A bone growth and device technology, applied in the field of absorbable orthopaedic devices, can solve the problem of not including the function of promoting bone growth and sterilization effect, and achieve the effect of excellent loading effect and promoting bone growth.

Active Publication Date: 2014-11-05
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] To sum up, the orthopedic devices reported so far do not have the function of promoting bone growth and bactericidal effect. Loading BMP and copper ions can make orthopedic devices have the above functions, but the selection of suitable carrier materials and suitable loading methods will not destroy the activity of BMP. The effective loading of BMP and copper ions is an urgent problem to be solved under the premise of

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The absorbable bone nail with antibacterial and bone growth-promoting functions is composed of medical pure magnesium rods and absorbable polymers. There is a porous ceramic layer on the surface of pure magnesium. The surface of the porous ceramic layer is B-type gelatin. The carrier and the functional loading layer loaded with bone morphogenetic protein and copper ions by electrophoresis-electrodeposition method, the preparation process is as follows:

[0024] 1) processing a pure magnesium rod with a diameter of 5mm into a bone screw with threads and nuts;

[0025] 2) Perform micro-arc oxidation treatment on magnesium bone nails. The main components of the electrolyte are 10g / L sodium silicate, 2g / LNaOH and 8g / L hydroxyapatite nanoparticles, the magnesium nails are immersed in it, and a voltage of 420V is applied for 15 minutes of micro-arc oxidation treatment to make the surface A layer of porous ceramic layer rich in magnesium oxide, magnesium silicate, and hydroxy...

Embodiment 2

[0030] The absorbable bone plate with antibacterial and bone growth-promoting functions is composed of medical AZ31B magnesium alloy plate and absorbable polymer. The surface of AZ31B magnesium alloy has a porous ceramic layer, and the surface of the porous ceramic layer is B-type gelatin As a carrier, the electrophoresis-electrodeposition method is used to load the functional loading layer of bone morphogenetic protein and copper ions. The preparation process is as follows:

[0031] 1) AZ31B magnesium alloy is hot-rolled or cut into a 1.0mm thick plate, and the bone plate with the required shape and structure is machined;

[0032] 2) Phosphating the surface of the magnesium alloy bone plate, the solution is NH 4 h 2 PO 4 120g / L, (NH 4 ) 2 SO 3 ·H 2 O30g / L, ammoniacal liquor (30%) 6mL / L, generate the porous ceramic layer based on the phosphate of magnesium, the average pore size of ceramic layer is 10 μ m, and average layer thickness is 30 μ m;

[0033] 3) Dissolve 2g o...

Embodiment 3

[0037] The absorbable orthopedic device with antibacterial and bone growth-promoting functions is composed of medical AZ31B magnesium alloy wire and absorbable copolymer of polylactic acid and polyglycolic acid (PLGA). The surface of the magnesium alloy wire has a porous ceramic layer. The surface of the porous ceramic layer is a functional loading layer with B-type gelatin as a carrier and loaded with bone morphogenetic protein and copper ions by electrophoresis-electrodeposition method. The preparation process is as follows:

[0038] 1) AZ31B magnesium alloy is drawn into a wire with a diameter of 0.3mm;

[0039] 2) Perform micro-arc oxidation treatment on the magnesium wire. The main components of the electrolyte are 10g / L sodium silicate and 2g / LNaOH. The magnesium wire is immersed in it, and a voltage of 380V is applied for 10 minutes of micro-arc oxidation treatment, so that a layer rich in magnesium oxide is formed on the surface in situ. , Magnesium silicate porous ce...

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PUM

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Abstract

The invention relates to an absorbable orthopedic apparatus material having antibiosis and bone growth promotion functions, and a preparation method thereof. The orthopedic apparatus material is obtained by compounding medical pure magnesium or magnesium alloy with an absorbable high-molecular polymer, the surface of the pure magnesium or magnesium alloy has a porous ceramic layer, the surface of the porous ceramic layer is a functional load layer loaded with bone morphogenetic proteins and copper ions with B-type gelatin as a carrier by adopting an electrophoresis-electrodeposition process, the volume fraction of the pure magnesium or magnesium alloy is 1-99%, the micropore aperture and the thickness of the porous ceramic layer on the surface of the pure magnesium or magnesium alloy are 1-100[mu]m and 1-100[mu]m respectively, and the surface of the porous ceramic layer is the functional load layer loaded with bone morphogenetic proteins and copper ions with B-type gelatin as the carrier by adopting the electrophoresis-electrodeposition process. An orthopedic apparatus can slowly release copper ions having a sterilizing effect and bone morphogenetic proteins having a bone growth promotion effect in the use process, can be applied to restore and fix various bone injuries, and has a wide application prospect.

Description

technical field [0001] The invention relates to an absorbable orthopedic device with antibacterial and bone growth-promoting functions. The orthopedic device can be completely degraded and absorbed in the internal environment, and slowly releases bone morphogenetic protein that can promote bone growth and bactericidal effect during the degradation process. Copper ions are suitable for the repair and fixation of various bone injuries in the human body, and belong to the technical field of orthopedic instruments. Background technique [0002] In recent years, degradable bone injury repair and fixation materials have attracted more and more attention because of their excellent biocompatibility and no need for secondary surgery. The published patent CN102764454A and the published patent CN102871715A both mentioned a magnesium alloy reinforced high The degradable and absorbable orthopedic fixation device of molecular polymer has excellent fixation effect and degradable characteri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/16A61L31/02C25D13/04C23C28/00
Inventor 储成林李旋刘珣白晶郭超薛烽林萍华
Owner SOUTHEAST UNIV
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