Novel protoporphyrin derivative and preparation method thereof

Abstract

The invention discloses a novel protoporphyrin derivative and a preparation method thereof. The novel protoporphyrin derivative has a structure represented as follows. The novel protoporphyrin derivative has a good in-vivo orientation effect and a good biological utilization degree, can be used in research and development of anti-oxidation drugs. The preparation method is simple, is easy to operate, is free of a catalyst, is green and environmental-protective, is suitable for industrial production and is wide in application prospect.

Description

technical field [0001] The invention belongs to the field of organic synthesis, and in particular relates to a novel protoporphyrin derivative and a preparation method thereof. In particular, it relates to obtaining novel protoporphyrin derivatives by reacting protoporphyrin compounds with aromatic compounds. Background technique [0002] Protoporphyrin is a class of aromatic heterocyclic compounds with a conjugated macrocyclic structure. Natural protoporphyrin is an effective component of hematoporphyrin derivatives, which widely exists in cells and organs related to energy transfer in organisms. The biosynthesis of protoporphyrin in vivo originates from 5-aminolevulinic acid (5-ALA). After a series of enzyme actions, protoporphyrin IX is finally generated on the mitochondria, and protoporphyrin IX and ferrous ions are formed in the ferrous Heme can be produced under the action of ferrochelatase. As a cofactor, heme can be combined with proteins, such as hemoglobin, myog...

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Problems solved by technology

[0003] The preparation of protoporphyrin derivatives usually utilizes condensation or addition reactions, but both require the use of catalysts and solvents, such as rhenium decacarbony

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