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A kind of preparation method of γ-polyglutamic acid-based organic phase nanogel

A polyglutamic acid-based, nano-gel technology is applied in the field of combining polymer materials and molecular self-assembly science, and achieves the effects of convenient use, simple preparation process, and easy-to-obtain raw materials.

Active Publication Date: 2017-04-19
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the gel systems of γ-polyglutamic acid and its derivatives are hydrogels at present, and there are few reports on the preparation of γ-polyglutamic acid-based organic phase gels.

Method used

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  • A kind of preparation method of γ-polyglutamic acid-based organic phase nanogel
  • A kind of preparation method of γ-polyglutamic acid-based organic phase nanogel
  • A kind of preparation method of γ-polyglutamic acid-based organic phase nanogel

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Effect test

Embodiment 1

[0019] A preparation method of γ-polyglutamic acid-based organic phase nanogel, the specific preparation steps are as follows:

[0020] Select a γ-polyglutamic acid macromolecule with a molecular weight of 120kDa, add dimethyl sulfoxide solvent, and dissolve at 55°C for 8 hours to obtain a 2 mg / mL γ-polyglutamic acid solution; then add folic acid to the solution to make the folic acid The content is 1mg / mL, and then the precipitant absolute ethanol is added dropwise to the above solution at 10μL / min, and the dropping amount is 1.5 times the volume of the mixed solution, so as to promote the self-assembly of γ-polyglutamic acid and folic acid in the mixed solution An organic phase nanogel is formed.

Embodiment 2

[0022] A preparation method of γ-polyglutamic acid-based organic phase nanogel, the specific preparation steps are as follows:

[0023] Select a γ-polyglutamic acid macromolecule with a molecular weight of 250kDa, add dimethyl sulfoxide solvent, and dissolve it at 80°C for 7 hours to obtain a 5 mg / mL γ-polyglutamic acid solution; then add folic acid to the solution to make the folic acid The content is 3mg / mL, and then the precipitant absolute ethanol is added dropwise to the above solution at 20μL / min, and the dropping amount is twice the volume of the mixed solution, so as to promote the self-assembly of γ-polyglutamic acid and folic acid in the mixed solution Formation of organic phase nanogels, digital photographs as figure 1 shown.

Embodiment 3

[0025] A preparation method of γ-polyglutamic acid-based organic phase nanogel, the specific preparation steps are as follows:

[0026] Select a γ-polyglutamic acid macromolecule with a molecular weight of 400kDa, add dimethyl sulfoxide solvent, and dissolve at 100°C for 6 hours to obtain a 8 mg / mL γ-polyglutamic acid solution; then add folic acid to the solution to make the folic acid The content is 4mg / mL, and then the precipitating agent acetone is added dropwise to the above solution at 30μL / min, and the dropping amount is 3 times the volume of the mixed solution, so as to promote the self-assembly of γ-polyglutamic acid and folic acid in the mixed solution to form organic Phase nanogel, gel TEM picture as figure 2 shown.

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Abstract

The invention provides a method for preparing gamma-polyglutamic acid-based organic phase nano gel. The preparation method comprises the following steps: dissolving gamma-polyglutamic acid into a good solvent dimethylsulfoxide, subsequently adding a proper amount of template molecules into the solution, thereby obtaining a mixed solution; and dropwise adding precipitant into the mixed solution to prompt the gamma-polyglutamic acid and the template molecules to self-assemble, thereby preparing the gamma-polyglutamic acid-based organic phase nano gel. The method is simple and convenient to carry out and mild in condition, provides a novel and feasible way for preparing gamma-polyglutamic acid-based gel, and has a wide application prospect.

Description

technical field [0001] The invention relates to a preparation method of a gamma-polyglutamic acid-based organic phase nanogel, which belongs to the field of combination of polymer materials and molecular self-assembly science. [0002] technical background [0003] Gel is a kind of substance between liquid and solid. According to the different types of solvents in the gel, it can be divided into hydrogel and organic gel, and can also be divided into physical gel and chemical gel. Among them, the physical gel forms a three-dimensional network structure through self-assembly in the solution through intermolecular forces, such as electrostatic force, hydrophilic-hydrophobic force, van der Waals force, hydrogen bond interaction, and π-π stacking effect. , sewage treatment, sustained release, molecular devices, food and other fields have broad application prospects (Macromolecules, 2010, 43, 5396-5404; Biomacromolecules, 2012, 13, 3552-3561; J.Am.Chem.Soc., 2011, 133, 16054-16061...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J3/09C08L77/04C08K5/3462
Inventor 刘晓亚孙家娣孟龙李杨崔燕顾瑶魏玮罗静
Owner JIANGNAN UNIV