A method for separating L-glutamic acid and L-pyroglutamic acid from L-glutamic acid refining mother liquor

A technology for pyroglutamic acid and glutamic acid, which is applied in the field of separation of L-glutamic acid and L-pyroglutamic acid, can solve problems such as the inability to provide technical solutions, and achieve the effect of raising costs and increasing energy consumption

Active Publication Date: 2015-12-09
BENGBU BBCA MEDICINE SCI DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The above invention has certain reference significance for the conversion of low-concentration glutamic acid contained in L-glutenic acid refining mother liquor to L-pyroglutamic acid to be solved by the present invention, but none of them can provide a direct technical solution path

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] 1) Vacuum concentrate 1000kg of the refined mother liquor that glutenic acid has been used for many times, concentrate to 200kg, cool down to 16°C for crystallization, at this time, solids are precipitated, with glutamic acid as the main component and L-pyroglutamic acid as the main component The crude product of the mixture of impurities is centrifuged to obtain the crude product of L-glutamic acid and the mother liquor after centrifugation. The mother liquor is used for the coking reaction in the next step. The solid crude product was washed with water to obtain pure L-glutamic acid. After drying, the weight is 15kg, and the content is 99.2%.

[0038] 2) Add 185kg of the mother liquor after separation of glutamic acid into the coking reaction kettle, seal it, heat it to 120°C, 2.5×10 5 Insulated coking reaction under Pa pressure for 3 hours, cooled to 80°C, concentrated in vacuo, concentrated to remove 92.5kg of water to obtain a concentrated solution containing L-p...

Embodiment 2

[0040] The refined mother liquor 1000kg that glutenic acid is applied mechanically for many times is carried out vacuum concentration, concentrates to 167kg. Cool down to 18°C ​​for crystallization. At this time, solids precipitate out. The crude product is a mixture of glutamic acid as the main component and L-pyroglutamic acid as the main impurity. Centrifuge to obtain the crude product of L-glutamic acid and the mother liquor after centrifugation. . The mother liquor is used for the coking reaction in the next step. The solid crude product was washed with water to obtain pure L-glutamic acid. After drying, the weight is 16kg, and the content is 99.1%.

[0041] Add 151kg of the mother liquor after separation of glutamic acid into the coking reaction kettle, seal it, heat it to 120°C, 2.0×10 5 Heat preservation and coking reaction under Pa pressure for 3 hours, cool down to 80°C, concentrate in vacuo, concentrate and remove 75.5kg of water to obtain a concentrated solution...

Embodiment 3

[0043] The refined mother liquor 1000kg that glutenic acid is applied mechanically for many times is carried out vacuum concentration, concentrates to 167kg. Cool down to 15°C for crystallization. At this time, solids are precipitated. The crude product is a mixture of glutamic acid as the main component and L-pyroglutamic acid as the main impurity. Centrifuge to obtain the crude product of L-glutamic acid and the mother liquor after centrifugation. . The mother liquor is used for the coking reaction in the next step. The solid crude product was washed with water to obtain pure L-glutamic acid. After drying, the weight is 16kg, and the content is 99.2%.

[0044] Add 151kg of the mother liquor after separation of glutamic acid into the coking reaction kettle, seal it, heat it to 130°C, 3.0×10 5 Heat preservation and coking reaction under Pa pressure for 5 hours, cool down to 80°C, concentrate in vacuo, concentrate and remove 75.5kg of water to obtain a concentrated solution ...

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Abstract

The invention relates to a method for separating L-glutamic acid and L-pyroglutamic acid from a glutamic acid refinement mother solution. The method comprises the following steps: 1) carrying out vacuum concentration on the glutamic acid refinement mother solution, cooling to crystallize, and centrifugating, wherein the solid is the L-glutamic acid crude product, and the liquid is for later use; 2) washing the L-glutamic acid crude product with water to obtain pure L-glutamic acid; and 3) heating the liquid obtained in the step 1), carrying out pressurized pyrogenic reaction, cooling, concentrating, cooling to crystallize, centrifugating, collecting the precipitate, adding water to a saturated state, recrystallizing, cooling, and carrying out centrifugal separation to obtain the L-pyroglutamic acid. The method is simple in technical process, and can well solve the problem of the separation technique for glutamic acid and pyroglutamic acid, thereby achieving the goals of enhancing the L-glutamic acid refinement yield and coproducing the L-pyroglutamic acid.

Description

technical field [0001] The invention relates to a method for separating L-glutamic acid and L-pyroglutamic acid, in particular to a method for separating L-glutamic acid and L-pyroglutamic acid from L-glutamic acid refining mother liquor. Background technique [0002] Crude L-glutamic acid (L-glutamic acid) contains many other amino acid impurities. At the same time, the appearance of glutenic acid is generally yellowish brown, and its light transmittance is far from meeting the requirements of food-grade L-glutamic acid. Therefore, it is necessary to - Gluten acid is refined to prepare food-grade L-glutamic acid. In the process of refining L-glutamic acid into food-grade L-glutamic acid, the refining solvent is water. In the article "Preparation of L-pyroglutamic acid and its application and development", Feng Dayan described in detail the mechanism of easy production of L-pyroglutamic acid by intramolecular dehydration of glutamic acid during the refining process of L-glu...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C227/40C07C229/24C07D207/28
Inventor 韦亚锋汪洪湖江立新夏继祥
Owner BENGBU BBCA MEDICINE SCI DEV
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