Pharmaceutical composition for treating tuberculous pleuritis and preparation method thereof

A technology for tuberculous pleurisy and composition, which is applied in the field of traditional Chinese medicine composition for treating tuberculous pleurisy and the field of preparation thereof, can solve the problems of tuberculous exudative pleurisy without a better formula, unsatisfactory curative effect, etc., achieves reduction of pleural adhesion, The effect of fast absorption of pleural effusion and safe medication

Inactive Publication Date: 2014-12-10
强红枫
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In short, Chinese medicine has achieved good curative effect in the treatment of this disease, but the curative effect of existing drugs in reducing the adverse reactions of pleural effusion absorption and shortening the course of the disease is not ideal. no better formula yet

Method used

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  • Pharmaceutical composition for treating tuberculous pleuritis and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The preparation of embodiment 1 Chinese medicine extract

[0017] Weigh Bupleurum 5kg, Radix Paeoniae Alba 3kg, Atractylodes Rhizoma Atractylodes Rhizoma 3kg, Forsythia 3kg, Schisandra chinensis 1.8kg, Lycium barbarum 2kg, Rock iris 1.8kg, Scutellaria baicalensis 2.6kg, Astragalus 2.6kg, Campanulaceae 2kg, Peucedanum 1.8kg, Fangji 1.8kg, mulberry branch 2kg, psyllium 3kg, Poria cocos 3kg, Eupatorium 3kg, Scrophulariae 3kg, Cimicifuga 2kg, Burnet 2kg, Commelina 1.8kg, Dandelion 2kg, Weeping grass 1.6kg, Golden buckwheat 2kg, Haijinsha 2kg, Kochia chinensis 2kg, coix seed 2kg, mulberry skin 1.8kg, winter melon skin 2kg, corn silk 2kg, madder 2kg, fisheye grass 2kg, sungrass 1.8kg, Puhuang 2kg, Liu Jinu 2kg, Chuanxiong 2kg, Salvia miltiorrhiza 2kg, Safflower 1.6kg, Curcuma 2kg, Yamatohong 1.6kg, mix, add 8 times the amount of water and decoct with slow fire for 2 hours, repeat 2 times, combine decoction, 0.08MPa, reduce pressure and concentrate to The relative density is ...

Embodiment 2

[0018] The preparation of embodiment 2 Chinese medicine tablet

[0019] prescription:

[0020] Chinese herbal extract 100g

[0021] Mannitol 120g

[0022] Sucrose 150

[0023] Sodium carboxymethyl starch (add first) 20g

[0024] (Add later) 10g

[0025] Microcrystalline Cellulose 80g

[0026] Sodium lauryl sulfate (add first) 1g

[0027] (Add later) 1g

[0028] 5% starch slurry appropriate amount

[0029] Preparation process: crush the Chinese medicine extract prepared in Example 1 through a 160-mesh sieve, pass through a 100-mesh sieve with mannitol, sucrose, sodium carboxymethyl starch, microcrystalline cellulose, and sodium lauryl sulfate, and set aside; weigh the traditional Chinese medicine Extract, mannitol, sucrose, microcrystalline cellulose, 2 / 3 sodium carboxymethyl starch, 1 / 2 sodium lauryl sulfate, mix well, add 5% starch slurry to make soft material, pass 20 Make wet granules with a mesh sieve, ...

Embodiment 3

[0030] Embodiment 3 The curative effect research of Chinese medicine of the present invention to tuberculous pleurisy

[0031] Tuberculous pleurisy was confirmed in 58 patients by X-ray, CT and ultrasound pleural effusion examination, including 39 males and 19 females; aged 21-53 years, with an average of 32.7 years; the course of disease was 13-40 days, with an average of 32 days. All patients were randomly divided into the control group (29 cases) and the test group (29 cases). There was no significant difference between the two groups in terms of gender, age, course of disease, and condition, and they were comparable. Patients in the control group were treated with conventional western medicine, that is, oral anti-tuberculosis drug isoniazid 0.3-0.4g, once a day; rifampicin 0.45-0.60g, once a day; ethambutol 0.75g, once a day. times; pyrazinamide 0.75g, 2 times a day; at the same time, pleural effusion was extracted by thoracentesis, 2 to 3 times a week. Patients in the te...

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Abstract

The invention discloses a pharmaceutical composition for treating the tuberculous pleuritis and a preparation method thereof. The pharmaceutical composition comprises active ingredients and pharmaceutically acceptable auxiliary materials. The active ingredients are prepared from the following Chinese herbal medicines: Chinese thorowax root, radix paeoniae alba, bighead atractylodes rhizome, fructus forsythiae, the fruit of Chinese magnoliavine, the fruit of Chinese wolfberry, purple bergenia rhizome, scutellaria baicalensis, buerger pipewort flower, platycodon grandiflorum, radix peucedani, the root of fangji, ramulus mori, plantago seed, poria cocos, hiraute shiny bugleweed herb, radix scrophulariae, rhizoma cimicifugae, sanguisorba officinalis and the like. The pharmaceutical composition enables pleural effusion to be sufficiently absorbed and meanwhile, can reduce the adverse reaction of absorption of the pleural effusion, shorten the course of the disease, reduce pleural adhesion, pleural thickening and chest pain and achieve the purpose of healing the tuberculous pleuritis.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating tuberculous pleurisy and a preparation method thereof. Background technique [0002] Tuberculous pleurisy is an exudative inflammation caused by Mycobacterium tuberculosis directly invading the pleura from the primary lesion near the pleura, or spreading to the pleura via hematogenous lymphatic vessels. Most tuberculous pleurisy is acute. The symptoms are mainly systemic poisoning symptoms of tuberculosis and local symptoms caused by pleural effusion. The symptoms of tuberculosis poisoning are mainly manifested as fever, chills, sweating, fatigue, loss of appetite, and night sweats. Local symptoms include chest pain, dry cough, and dyspnea. Chest pain is usually located below the anterior axillary line or posterior axillary line, where the breathing movement of the thorax is the largest. I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P31/06
Inventor 段懿玲强红枫
Owner 强红枫
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