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Electronic sensor and gene detection method based on electronic sensor

An electronic sensor and detection method technology, applied in the field of electronic sensor and gene detection, can solve the problems of low ion current and difficulty in accurate detection, and achieve the effects of high sensitivity, accurate gene detection results and high precision

Active Publication Date: 2014-12-17
SHANGHAI TURTLE TECH
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Problems solved by technology

Moreover, the ionic current itself is very low, at 10 -11 to 10 -10 Ampere (A) order of magnitude, it is also very difficult to accurately detect

Method used

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  • Electronic sensor and gene detection method based on electronic sensor
  • Electronic sensor and gene detection method based on electronic sensor
  • Electronic sensor and gene detection method based on electronic sensor

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Embodiment Construction

[0071] In order to make the object, technical solution and advantages of the present invention clearer, various embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings. However, those of ordinary skill in the art can understand that, in each implementation manner of the present invention, many technical details are provided for readers to better understand the present application. However, even without these technical details and various changes and modifications based on the following implementation modes, the technical solution claimed in each claim of the present application can be realized.

[0072] A first embodiment of the invention relates to an electronic sensor such as image 3 As shown, the electronic sensor includes an ion-sensitive field-effect transistor (ISFET), and a first groove is etched on the nanowire channel 304 between the source 302 and the drain 303, and the bottom of the first groove has One ...

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Abstract

The invention relates to the field of biological detection and discloses an electronic sensor and a gene detection method based on the electronic sensor. The electronic sensor comprises ISFET, a nano-wire channel between a source electrode and a drain electrode of the ISFET is provided with a first groove by etching, the bottom of the first groove is provided with nano-pores, or is provided with chemical molecules or is provided with nano-pores and chemical molecules arranged at the nano-pores so that it is avoided that the DNA molecules smoothly slide at a high rate from one side to the other side of the chemical molecules or the nano-pores without control, only after a single-chain DNA to be tested successfully matches a detection basic group, a basic group can be moved forward by the chemical molecules and a matching process of the detection basic group and the basic group of the single-chain DNA to be tested can be accurately detected so that the gene detection result is more accurate, a detection precision is high and detection sensitivity is high.

Description

technical field [0001] The invention relates to the field of biological detection, in particular to an electronic sensor and a gene detection method based on the electronic sensor. Background technique [0002] With the development of science and technology, deoxyribose nucleic acid (Deoxyribonucleic acid, abbreviated as DNA) sequencing has become a routine research project in biomedical research laboratories all over the world. The reason for this phenomenon may be due to the rapid development of sequencing technology, which leads to the falling cost of owning sequencing equipment, or it may be due to the falling cost of biochemicals and other necessities required to perform sequencing. The cost of sequencing the entire human genome, based on so-called first-generation sequencing technologies, fell at a rate between 2001 and 2007 consistent with Moore's Law for microelectronics. As can be seen from the figure, the next-generation massively parallel sequencing technology en...

Claims

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Application Information

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IPC IPC(8): C12M1/34C12Q1/68
CPCG01N33/48721G01N27/4145C12Q1/6869G01N27/4146C12Q2565/607C12Q2565/631
Inventor 张世理吴东平章贞克劳斯·安德斯·尤特拉尔夫·西艾切
Owner SHANGHAI TURTLE TECH
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