Closed loop nerve stimulation system

Abstract

The invention belongs to the technical field of implantable medical instruments, and provides a closed loop deep brain stimulation system which can collect physiological signals of patients, adjust pulse stimulation parameters in real time and display data, store the data, design an optimization algorithm and update embedded programs in real time through an upper computer, and particularly relates to a closed loop nerve stimulation system. According to the closed loop nerve stimulation system, two closed loop work modes are provided; in one work mode, an implantable nerve stimulator carries out embedded algorithm data processing to form closed loop control; in the other work mode, the implantable nerve stimulator uploads the collected data to the upper computer through a wireless communication module, and then the upper computer carries out algorithm processing and then controls the stimulation parameters through the wireless communication module to form a closed loop. The closed loop nerve stimulation system can be used for closed loop electrical stimulation treatment of nervous system diseases or clinical research or animal research of a closed loop stimulation method and can provide a good platform for the research of the closed loop stimulation method.

Description

technical field [0001] The invention relates to an implanted medical instrument, in particular to an implanted closed-loop nerve stimulation system. Background technique [0002] The effectiveness of deep brain stimulation therapy in the treatment of Parkinson's disease, epilepsy and other neurological diseases depends on the accuracy of electrode positioning on the one hand, and on the other hand, appropriate stimulation parameters are also an important factor to achieve good curative effect. At present, the "open-loop" stimulation mode is generally used clinically, that is, the electrical stimulation treatment parameters are manually adjusted by doctors based on clinical experience, and the treatment parameters generally remain unchanged until the next patient follow-up. In this "open-loop" stimulation mode, the patient's program control cycle is longer, and parameter adjustment cannot respond to changes in the condition in a timely manner, resulting in the inability to ex...

AI Technical Summary

Problems solved by technology

The research on closed-loop stimulation methods has been going on for many years. However, many studies are based on mathematical analysis of offline data. The heavy data processing algorithm is not suitable for embedded programs, making the real closed-loop stimulation far away from clinical application.

In addition, a major challenge in the design of closed-loop systems is that the closed-loop feedback objects and effectors are still being explored. Whether it is clinical application or animal experimental research, after implanting a closed-loop neurostimulator, it may be necessary to re-select effective feedback factors and change Corresponding data processing algorithms, however, many of the existing technologies are fixed feedback control methods, which cannot flexibly update the algorithm or provide personalized closed-loop feedback control methods for specific patients

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