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Latanoprost eye drop

A technology for latanoprost and eye drops, which is applied in the directions of aerosol delivery, medical preparations of inactive ingredients, organic active ingredients, etc. Overcome the short residence time, improve water solubility, and inhibit the effect of decomposition

Inactive Publication Date: 2015-01-21
SUNSHINE LAKE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Because the commercially available latanoprost eye drops are inconvenient to preserve, and because latanoprost is insoluble in water, and is easy to be adsorbed on the resin container, while the common eye drops have a short retention time of the eye drug and have a low bioavailability. Therefore, it is desired to develop latanoprost eye drops that can be stored at room temperature and have excellent stability, so as to solve the problem of solubility in water, the problem of drug concentration reduction due to the adsorption of the container, and the problem of low bioavailability

Method used

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  • Latanoprost eye drop

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Latanoprost 0.005%, Tween-80 0.1%, Polycarbophil 0.9%, Disodium EDTA 0.1%, Sodium Dihydrogen Phosphate 0.5%, Disodium Hydrogen Phosphate 0.4%, Benzalkonium Chloride 0.02%, the balance is water;

[0035] Material name

Prescription ratio (%)

effect

Latanoprost

0.005

Main drug

Tween 80

0.1

Surfactant

Polycarbophil

0.9

thickener

Disodium edetate

0.1

antioxidant

Sodium dihydrogen phosphate

0.5

Osmotic pressure and pH regulator

Disodium phosphate

0.4

Osmotic pressure and pH regulator

Benzalkonium chloride

0.002

preservatives

Water for Injection

add up to 100

solvent

[0036] The preparation method is as follows:

[0037] 1): Take out latanoprost with a capillary tube, accurately weigh latanoprost, benzalkonium chloride, and Tween-80 to the bottom of the beaker according to the prescription amount, then add a small amount of wat...

Embodiment 2

[0042] Latanoprost 0.005%, Tween-80 0.1%, Polycarbophil 0.1%, Poloxamer 0.2%, Disodium EDTA 0.1%, Sodium Dihydrogen Phosphate 0.5%, Disodium Hydrogen Phosphate 0.4%, the balance is water;

[0043] The preparation method is the same as in Example 1.

Embodiment 3

[0045] Latanoprost 0.005%, Tween-80 0.3%, Polycarbophil 0.05%, Poloxamer 0.2%, Disodium EDTA 0.15%, Sodium Dihydrogen Phosphate 0.4%, Disodium Hydrogen Phosphate 0.32%, benzalkonium chloride 0.02%, the balance is water;

[0046] Prepare with embodiment 1.

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Abstract

The invention discloses a latanoprost-containing in situ gel eye drop. The eye drop contains an active component latanoprost, an antioxidant, a surfactant, a gel matrix, an adhesive, a pH adjusting agent and an optional antiseptic. The eye drop has good stability, can avoid the drug concentration reduction due to the adsorption of a container, and solves the defects of short retention time of drugs in eyes and low bioavailability of ordinary eye drops.

Description

technical field [0001] The invention relates to an in-situ gel eye drop of latanoprost, in particular to an in-situ gel eye drop containing an antioxidant and a surfactant and a preparation method thereof, belonging to the field of pharmaceutical preparations. Background technique [0002] Latanoprost is a prostaglandin glaucoma treatment drug and a selective FP receptor agonist that reduces intraocular pressure by promoting aqueous humor outflow. There are 0.005% eye drops on the market, but the stability is poor, so the storage condition is to store in a dark and cool place in a dark environment, and the validity period is short. [0003] Latanoprost is unstable in aqueous solution, and resin containers are easy to absorb. Patents 1 to 6 disclose various preparations containing latanoprost, mainly to improve the stability of latanoprost. [0004] Patent 1: CN201080040579 discloses a stable aqueous eye drop of latanoprost, which contains latanoprost, a surfactant and an al...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/5575A61K47/44A61K47/34A61K47/36A61P27/06
Inventor 赵玉姣
Owner SUNSHINE LAKE PHARM CO LTD
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