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Process for preparing xiaojin pill

A preparation process and group technology, applied in the field of preparation of Xiaojin Pills, can solve problems such as uneven color, obvious difference in odor, and difficulty in ensuring quality uniformity, and achieve the effect of good mixing uniformity, simple operation, and improved quality uniformity

Active Publication Date: 2015-01-28
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, in the production process, due to the properties and dosage ratio of the above-mentioned medicinal materials, the mixing uniformity of Xiaojin Wan powder is not good, and the quality uniformity is difficult to guarantee, which leads to uneven color, obvious difference in smell and batch-to-batch difference in Xiaojin Wan products. major issues

Method used

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  • Process for preparing xiaojin pill
  • Process for preparing xiaojin pill
  • Process for preparing xiaojin pill

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Example 1: Preparation of Xiaojinwan medicinal-flavored composite particle powder

[0030] Method 1: Weigh the prescribed amount of Shiwei medicinal materials and crush them into medium powder for use. Put Wulingzhi, Fragrant Ink, Radix Astragali, Angelica sinensis, Dilong and starch (add 25g of starch according to the total powder of every 100g of prescription), put them in a vibrating drug ultra-fine pulverizer, and pulverize them for 60min; Seed, sweetgum, frankincense, myrrh, and continue to pulverize for 2 minutes to obtain Xiaojinwan composite particle powder.

[0031] Method 2: Weigh the prescription amount of Shiwei medicinal materials, and pulverize them into medium powder for use. Put Wulingzhi, fragrant ink, Radix chinensis and starch (add 25g of starch according to the total powder of every 100g of prescription), put them in a vibrating drug ultra-fine pulverizer, and pulverize for 50min; Frankincense, myrrh, angelica, and earthworm, and continue to pulver...

Embodiment 2

[0034] Embodiment 2: the preparation of the small golden pill powder of different production technology and its preparation

[0035] 1 Instruments and materials

[0036] SYFM-8Ⅱ Vibrating Drug Ultrafine Mill (Jinan Beili Company); Agilent 1260 High Performance Liquid Chromatograph (USA); METTLER-TOLEDO AB265-S Electronic Analytical Balance (Switzerland); FST-Ⅲ-10 Precision Ultrapure water machine (Shanghai Fushite); Tu-1901 UV-Vis spectrophotometer (Beijing Puxi); high-speed multi-function grinder (Shanghai Bingdu Electric Co., Ltd.); ADCI series automatic color difference meter (Beijing Chentek) Instrument Technology Co., Ltd.); BT-9300ST laser particle size distribution analyzer (Dandong Baite Instrument Co., Ltd.); ZJ-type strain-controlled direct shearing instrument (Nanjing Soil Instrument Factory Co., Ltd.); DHG-101-type electric heating constant temperature blast drying oven ( Gongyi Yingyu Yuhua Instrument Factory); Electric Heating Constant Temperature Water Bath (Ji...

Embodiment 3

[0044] Example 3: Characterization of color difference between Xiaojinwan ordinary powder and composite particle powder

[0045] 1. Sampling method: Combined with the "Guidelines for Drug Sampling" promulgated by the State Food and Drug Administration, a combination of multi-point single sampling and multiple sampling at the same point is adopted. Stack the powder into a cone shape, and take samples from different parts of the cone, such as the top, middle, bottom, front, back, left, and right, for a total of 7 points, and then select four fixed points for sampling, and take 3 times for each point. A total of 19 sampling points.

[0046] 2. Color difference measurement: ADCI series automatic color difference meter is used to measure the color, and the color is expressed according to the CIE1976L*a*b* chromaticity space. The color difference is calculated by the settlement formula set by the instrument, and dE* represents the comprehensive color difference value.

[0047] 2.1...

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Abstract

The invention provides a process for preparing xiaojin pills. The process comprises the following steps: a, weighing raw material medicines, that is, muskone, momordica cochinchinensis (shells and oil are removed), prepared kusnezoff monkshood roots, resina liquidamberis, frankincense (prepared), myrrh (prepared), trogopterus dung (fried with vinegar), angelica sinensis (fried with alcohol), earthworms and fragrant ink; b, dividing the raw material medicines into materials which are easy to crush and materials which are hard to crush; c, crushing the raw medicine materials into medicine powder of 10-100 meshes by using an ordinary crusher; d, putting the materials which are easy to crush into a vibration type medicine superfine crusher, crushing, further adding the materials which are hard to crush, and crushing, thereby obtaining xiaojin pill composite particle powder; and e, and adding pharmaceutically acceptable auxiliary materials into the powder, thereby preparing pills. The content and the uniformity of the xiaojin pills prepared from the composite particle powder are both superior to those of artificial powder pills, and the result shows that a powder mixing method based on a particle composite technique is simple to operate, relatively good in mixing uniformity and beneficial to improving the quality uniformity of traditional Chinese medicine preparations when being compared with a conventional method.

Description

technical field [0001] The invention relates to a preparation process of Xiaojin pills. Background technique [0002] The preparation process of traditional Chinese medicine pills mainly includes crushing-mixing-pellet making, among which mixing is the key link to determine the "quality uniformity" of the pills. Because traditional Chinese medicine pills are all powdered into medicine, the source of powder is complex, and the properties vary greatly, such as wide particle size distribution, different shapes, disparity in density, high adhesion, strong cohesion, heat agglomeration and hardening, oil spillage after crushing oil drugs, etc. , which has a serious impact on the mixing uniformity of the powder, which makes it difficult to guarantee the quality uniformity of the traditional Chinese medicine pills, thereby affecting the clinical efficacy. [0003] Xiaojinwan is contained in the "Chinese Pharmacopoeia" (2010 edition), and is composed of ten medicinal materials such ...

Claims

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Application Information

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IPC IPC(8): A61K36/714A61K9/20A61P29/00A61P15/14A61P35/00
CPCA61K9/2059A61K35/24A61K35/55A61K35/62A61K36/15A61K36/185A61K36/232A61K36/324A61K36/328A61K36/42A61K36/714A61K2236/15A61K2300/00
Inventor 韩丽王小平郝月莆任桂林杨明郭治平
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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