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Medicated leaven pure powder superfine decoction piece and preparation method thereof

The technology of Shenqu and ultra-micro is applied in the field of ultra-micro decoction pieces of Shenqu pure powder and its preparation. , good stability

Inactive Publication Date: 2015-02-04
磐安县道地磐药中药研究所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The main purpose of the present invention is to overcome the low drug dissolution rate of Shenqu traditional Chinese medicine oral dosage forms in the prior art, the content of active ingredients is reduced, the bioavailability is low, and the process conditions of conventional ultrafine pulverization technology are not suitable for the preparation of Shenqu oral dosage forms. The active ingredients in the obtained oral dosage form are easy to decompose, there are many impurities, the content uniformity is poor, the stability is poor, etc., and a preparation process and preparation method of superfine decoction pieces of Shenqu pure powder are provided

Method used

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  • Medicated leaven pure powder superfine decoction piece and preparation method thereof
  • Medicated leaven pure powder superfine decoction piece and preparation method thereof

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preparation example Construction

[0032] The preparation method of Divine Comedy extract in embodiment 1-3 comprises the following steps:

[0033]Divine Comedy is obtained by the following preparation method: Weigh by weight: 100kg of flour, 4kg of bitter almond, 4kg of red bean, 7kg of fresh Artemisia annua, 7kg of fresh spicy Polygonum, 7kg of fresh cocklebur; Add 500L of water to Polygonum and fresh cocklebur, decoct for 50 minutes, filter, and concentrate the filtrate to 50L under reduced pressure to obtain a concentrated solution; crush the bitter almond and red bean into bitter almond powder and red bean powder, and the bitter almond powder And the red bean powder is powder passed through a 50-mesh sieve; the concentrated solution is mixed with the flour, bitter almond powder and red bean powder, kneaded into a ball, tightly wrapped in paper, at 32-35 ° C, naturally Ferment for 5-7 days, take it out, put it into a slicer, cut it into small pieces, and let it dry naturally. The active extract of the Divi...

Embodiment 1

[0036] Preparation Process:

[0037] The dried active extract of Shenqu is crushed to a particle size of less than 300 microns, sterilized by radiation, and then ultrafinely pulverized to 40 microns in a jet mill, and 90% of the particles with a particle size of less than 65 microns accumulate to obtain superfine decoction pieces ;

[0038] Among them, the temperature of vacuum drying is 100°C, and the pressure is 0.1mpa; the conditions of ultrafine pulverization are: pulverization temperature 20°C, pressure when entering the ultrafine pulverizer is 1.5Mpa, pulverization pressure 3Mpa, air velocity 220m / s, pulverization The time is 1.5h;

[0039] The prepared ultrafine decoction pieces and auxiliary materials meeting the pharmaceutical requirements are prepared into tablets, capsules, or other oral constant-release dosage forms.

Embodiment 2

[0041] Preparation Process:

[0042] The dried active extract of Shenqu is crushed to a particle size of less than 300 microns, microwave sterilized, and then ultrafinely pulverized to 50 microns in a jet mill, and 95% of the particles with a particle size of less than 65 microns accumulate to obtain superfine decoction pieces ;

[0043] Among them, the temperature of vacuum drying is 90°C, and the pressure is 0.2mpa; the conditions of ultrafine pulverization are: pulverization temperature 20°C, pressure when entering the ultrafine pulverizer is 1.5Mpa, pulverization pressure 5Mpa, air velocity 260m / s, pulverization The time is 1.5h;

[0044] The prepared ultrafine decoction pieces and auxiliary materials meeting the pharmaceutical requirements are prepared into tablets, capsules, or other oral constant-release dosage forms.

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Abstract

The invention discloses a medicated leaven pure powder ultramicro decoction piece preparation method and a prepared product. The preparation method is as follows: crushing dried medicated leaven active extracts to the particle size below 300 microns, performing ultramicro-crushing in an airflow crusher to prepare a the ultramicro decoction piece, and the ultramicro-crushing conditions are as follows: the crushing temperature is 15-22 DEG C, the pressure is 1-2MPa when entering the ultramicro-crusher, the crushing pressure is 2-6MPa, the air flow velocity is 200-285m / s, and the crushing time is 1-3H. The oral medicament prepared by the preparation method has good effect, good dissolution property, good stability and high bioavailability, and the smell and taste of the oral medicament are improved.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to superfine decoction pieces of divine music pure powder and a preparation method thereof. Background technique [0002] "Divine Comedy" is a famous medicine for indigestion developed by Liu Yi, a famous doctor in Han Dynasty. However, when the Divine Comedy came out, it was inspired by the self-healing behavior of wild animals. After a period of time, Liu Yi found that the eggs in his chicken coop were often missing, so he observed carefully and found that it was a fire snake. So he decided to punish the snake. He made a few fake eggs with stones wrapped in lime, and coated a layer of egg white on the outside of the fake eggs, put them in the chicken coop, and then waited by the side. Soon, he saw the snake crawl into the chicken coop and swallow the fake eggs. After a while, the snake struggled painfully on the ground, and then it crawled into the gras...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61K36/704A61K9/00A61P1/14A61K36/282A61K36/28
CPCA61K36/00A61K9/143A61K9/145A61K9/2095A61K9/5089A61K36/899A61K2236/331A61K2236/51A61K2236/53
Inventor 傅苗青傅根元
Owner 磐安县道地磐药中药研究所