A kind of preparation method of nano silver chloride/chitosan fiber antibacterial dressing

A technology of chitosan fiber and silver chloride, which is applied in medical science, bandages, absorbent pads, etc., can solve the problems of poor particle fixation performance, difficult selective adsorption of silver ions, and easy fall-off, etc., to achieve good fixation performance and effective Favorable for selective adsorption and reduced accumulation

Active Publication Date: 2016-01-27
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chitosan is a polysaccharide with positively charged amino groups. Ordinary chitosan fibers are mostly prepared by high-temperature stretching and spinning process of alkaline sodium salt. Positively charged silver ions, and the nano-silver or nano-silver chloride particles formed on the smooth chitosan fiber surface have poor fixation performance and are easy to fall off

Method used

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  • A kind of preparation method of nano silver chloride/chitosan fiber antibacterial dressing
  • A kind of preparation method of nano silver chloride/chitosan fiber antibacterial dressing
  • A kind of preparation method of nano silver chloride/chitosan fiber antibacterial dressing

Examples

Experimental program
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Effect test

Embodiment 1

[0033] Surface Pretreatment of Chitosan Nonwoven Fabric

[0034] Get chitosan fiber non-woven fabric (120 g / m 2 ) 10*10cm 2 , respectively dipped in nitric acid + acetic acid and nitric acid + acetic acid + surfactant solution to pretreat the surface of the fiber, see attached table 1 for the pretreatment conditions.

[0035] Table 1 Chitosan fiber surface pretreatment conditions

[0036]

[0037] Surfactants 1, 2, and 3 are respectively used: alkanolamide, dodecylbenzenesulfonic acid, fatty alcohol polyoxyethylene ether, and the dosage is 0.1-0.5mol / L.

[0038] (1) When the concentration of surfactant 1 is 0.1mol / L, the acid concentration is 0.001mol / L, and the acid solution volume is 100mL for 1min, the weight loss of chitosan fiber is 1.14%. defects;

[0039] (2) When the concentration of surfactant 1 is 0.3mol / L, the acid concentration is 0.01mol / L, and the acid solution volume is 50mL for 3 minutes, the weight loss of chitosan fiber is 2.31%. defects;

[0040] (3...

Embodiment 2

[0048] Impregnation and Adsorption of Chitosan Fiber on Silver Salt

[0049] Take several pieces of pretreated chitosan non-woven fabric (10*10cm 2 , the pretreatment method is according to (4) and (7) in the embodiment 1), soaks in the silver nitrate solution of different initial concentrations respectively, takes a sample regularly, analyzes the residual silver ion concentration in the solution, the chitosan without pretreatment Non-woven fabric as a control sample;

[0050] The adsorption of silver ions by pretreated chitosan fiber is selective adsorption. Within the selected concentration range of silver ions, the adsorption speed of silver ions is very fast within 10 minutes, slows down after 20 minutes, and slows down after 30 minutes. The adsorption amount accounts for 95-97% of the total silver content of the solution, reaching the maximum equilibrium adsorption amount; the samples prepared by (4) and (7) pretreatment methods in Example 1 show no significant differenc...

Embodiment 3

[0056] Preparation of nano-silver chloride / chitosan fiber antibacterial material

[0057] Commonly used antibacterial dressings have a silver loading of 10-150mg / 10*10cm 2 , this work designed four different silver loadings 20, 60, 100, 150mg / 10*10cm 2 ;

[0058] (1) Using the method of (4) in Example 1 to pretreat the chitosan non-woven fabric (10*10cm 2 ), dipped in 40mL of 0.0048mmol / mL silver nitrate solution, drained, and dried with hot air to a water content of 30%; evenly sprayed with 8mL of 0.036mmol / mL sodium chloride solution, and chlorinated for 5min; washed with deionized water Afterwards, dry in vacuum to prepare the finished product;

[0059] The silver loading of the final product was 19.5 mg, the silver recovery rates of silver nitrate impregnation and chlorination reaction steps were 95.5% and 98.5% respectively, and the total silver recovery rate was 94.1%.

[0060] (2) Using the method of (4) in Example 1 to pretreat the chitosan non-woven fabric (10*10c...

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Abstract

The invention discloses a preparation method of a nano-silver chloride / chitosan fiber antibacterial dressing, which comprises the following steps: (1) pretreatment of the surface of chitosan fiber non-woven fabric: spraying acid solution on the surface of chitosan fiber , soak the surface of the non-woven fabric with the acid solution, wash it with deionized water after treatment for 1-5 minutes; (2) Soak the pre-treated non-woven fabric in 0.0048-0.036mmol / mL silver nitrate solution, and shake at room temperature for 30 minutes; (3) Take out the non-woven fabric and drain it, then dry it until the water content is 30%-40%; (4) Spray 0.036-0.27mmol / mL sodium chloride solution equal to the saturated water absorption on the surface of the non-woven fabric, The number of moles of sodium chloride is 1.2-1.5 times the number of moles of adsorbed silver, and the reaction is 5-10 minutes; (5) Spray deionized water for a quick rinse, drain, and vacuum-dry at 50-60°C. The silver recovery rate of the preparation method is high. The prepared nano-silver chloride antibacterial material has stable physical and chemical properties, good antibacterial (inhibition) performance, good fixation performance between silver chloride particles and chitosan fibers, and can be used as a medical wound dressing.

Description

technical field [0001] The invention belongs to the field of antibacterial material preparation, and in particular relates to a preparation method of nanometer silver chloride / chitosan fiber antibacterial dressing. Background technique [0002] Silver has good antibacterial function, broad-spectrum sterilization, and no drug resistance. Silver ion antibacterial agents and nano-silver antibacterial agents are the most commonly used silver-based antibacterial agents. Carriers of silver-based antibacterial agents include zeolite, phosphate, activated carbon and fiber materials. [0003] Silver ion antibacterial agents are widely used in anti-infection topical agents. However, the chemical properties of silver ions are lively, and it is easy to transform into a brown silver complex, which seriously affects the color of the wound skin after recovery. Moreover, for deep wounds, silver ions are easy to combine with wound muscle proteins, which is not conducive to wound healing. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/18A61L15/28A61L15/44
Inventor 郭养浩郑允权石贤爱
Owner FUZHOU UNIV
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