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A preparation method of bioglass with controlled drug release rate

A release rate, bio-glass technology, applied in pharmaceutical formulations, medical preparations of non-active ingredients, inorganic non-active ingredients, etc.

Active Publication Date: 2017-01-11
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to propose a method for preparing bioglass with controlled drug release rate in view of the complexity and dispersibility of nanoparticle synthesis at present

Method used

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  • A preparation method of bioglass with controlled drug release rate
  • A preparation method of bioglass with controlled drug release rate
  • A preparation method of bioglass with controlled drug release rate

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Experimental program
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Embodiment Construction

[0017] The invention will be further described below in conjunction with the examples and accompanying drawings; in this example, the release rate of the drug is verified by using methyl orange as a simulated drug.

[0018] A kind of preparation method of the bioglass of controlled drug release rate, this method comprises the following steps:

[0019] (1) Prepare 4 beakers A, B, C, and D, add 90mL of ethanol solution to each beaker, then dissolve 0.02g of the drug in 4 parts of ethanol solution, stir for 10 minutes to obtain a mixed solution;

[0020] (2) Add 2 mL tetraethyl orthosilicate dropwise to each beaker, and after the addition is completed, sonicate for 30 minutes in an ultrasonic water bath environment to obtain a uniform solution;

[0021] (3) Then add 323uL deionized water to beaker A; add 646uL deionized water to beaker B; add 969uL deionized water to beaker C; add 1292uL deionized water to beaker D, and continue ultrasonication for 30 minutes;

[0022] (4) Add 3...

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Abstract

The invention discloses a preparation method of bioglass for controlling drug release rate. The bioglass prepared by the method is basically kept unchanged in nanoparticle size along with successive increment of additive amount of de-ionized water, but a drug release curve reflects different rates and release amounts along with different additive amounts of the de-ionized water. The release rates are reduced in sequence along with increment of the additive amount of the de-ionized water. The preparation method is simple, the raw material cost is low, the whole preparation process is performed in an air atmosphere, and no special devices is required.

Description

technical field [0001] The invention relates to a preparation method of biological glass for controlling the release rate of drugs, which is used for controlling the release rate of drugs. Background technique [0002] For the current drug carrier materials, the controllable delivery and release of drugs is the core performance index. In a certain period of time, the release of the drug must be within a controllable rate range, so that the drug can fully play its role, so as to achieve the therapeutic effect of the disease. [0003] Nanomaterials have many advantages as drug carriers and have been extensively studied. Due to its large specific surface area, small size, and good shape. SiO has been studied more 2 Nanoparticles, polymer nanoparticles such as PLGA, and NaYF 4 or NaYF 4 with SiO 2 composite nanoparticles. Compared with these materials, bioglass nanospheres not only have uniform size, controllable morphology, and large specific surface area, but also have ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/02A61K47/04
Inventor 韩高荣李杨杨李彬彬李翔
Owner ZHEJIANG UNIV