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Huichun capsule and preparation method thereof

A technology for forgetfulness, kidney deficiency and low back pain, which can be used in capsule delivery, pharmaceutical formulations, medical preparations with inactive ingredients, etc.

Inactive Publication Date: 2015-03-04
HEILONGJIANG JIANGHENG PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The curative effect of Huichun Capsules on the market is not satisfactory due to the composition and process, and the preparation is prepared by traditional technology, which has the disadvantages of slow disintegration and low curative effect

Method used

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  • Huichun capsule and preparation method thereof
  • Huichun capsule and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031] Take 18g Gastrodia elata, 45g ferulae, 1.8g gecko, 25.2g curculigo, 63g bullwhip, 31.5g actinolite, 2.5g cistanche, 27g schisandra, 1.3g antler gum, 36g epimedium, 50.4 g of Acanthopanax extract g, Phellodendron 12.6g, crushed into 60 mesh coarse powder, extracted by carbon dioxide supercritical extraction, extraction pressure 30Mpa, extraction temperature 30°C, separator pressure 10Mpa, separator temperature 50°C, separation time 2 hours, carbon dioxide flow rate per hour 40L to obtain the extract; take the extract and dry it under reduced pressure at 60°C to obtain a dry paste; add 150g of mannitol to the dry paste, and use a high-energy nano-impact mill to pulverize it into a mixed dry paste powder with a particle size of 200-300nm; take the mixed dry paste powder , microcrystalline cellulose 45g, cross-linked polyvinylpyrrolidone 45g, cross-linked carmellose sodium 35g, mix well, wet granulate with 50% ethanol, dry at 60℃, add sodium carboxymethyl starch 7g, stearic ...

specific Embodiment 2

[0033] Take 18g Gastrodia elata, 45g ferulae, 1.8g gecko, 25.2g curculigo, 63g bullwhip, 31.5g actinolite, 2.5g cistanche, 27g schisandra, 1.3g antler gum, 36g epimedium, 50.4 g of Acanthopanax extract g, Phellodendron 12.6g, crushed into 60 mesh coarse powder, extracted by carbon dioxide supercritical extraction, extraction pressure 40Mpa, extraction temperature 40°C, separator pressure 20Mpa, separator temperature 60°C, separation time 4 hours, carbon dioxide flow rate per hour 50L to obtain the extract; take the extract and dry it under reduced pressure at 80°C to obtain a dry paste; add 200g of mannitol to the dry paste, and use a high-energy nano-impact mill to pulverize it into a mixed dry paste powder with a particle size of 200-300nm; take the mixed dry paste powder , microcrystalline cellulose 55g, cross-linked polyvinylpyrrolidone 55g, cross-linked sodium carboxymethylcellulose 45g, mix well, wet granulate with 70% ethanol, dry at 80℃, add sodium carboxymethyl starch ...

Embodiment 3

[0035] Take 18g Gastrodia elata, 45g ferulae, 1.8g gecko, 25.2g curculigo, 63g bullwhip, 31.5g actinolite, 2.5g cistanche, 27g schisandra, 1.3g antler gum, 36g epimedium, 50.4 g of Acanthopanax extract g, Phellodendron 12.6g, crushed into 60 mesh coarse powder, extracted by carbon dioxide supercritical extraction, extraction pressure 35Mpa, extraction temperature 35°C, separator pressure 15Mpa, separator temperature 55°C, separation time 3 hours, carbon dioxide flow rate per hour 45L to obtain the extract; take the extract and dry it under reduced pressure at 70°C to obtain a dry paste; add 175g of mannitol to the dry paste, and use a high-energy nano-impact mill to pulverize it into a mixed dry paste powder with a particle size of 200-300nm; take the mixed dry paste powder , microcrystalline cellulose 50g, cross-linked polyvinylpyrrolidone 50g, cross-linked sodium carboxymethylcellulose 40g, mix well, wet granulate with 60% ethanol, dry at 70℃, add sodium carboxymethyl starch ...

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Abstract

The invention discloses a Huichun capsule and a preparation method thereof. The Huichun capsule is characterized in that 18g of gastrodia elata, 45g of ferulic, 1.8 g of geckos, 25.2 g of curculigo orchioides, 63 g of bull pizzle, 31.5 g of actinolite, 2.5 g of herba cistanches, 27 g of schisandra, 1.3 g of antler glue, 36 g of epimedy, 50.4 g of medofenoxate extracts and 12.6 g of phellodendron barks are taken, extracted with a carbon dioxide supercritical extraction method, dried under reduced pressure, smashed into nano dry paste by a high-energy nano impact mill and added with functional auxiliaries, and the mixture is prepared into the Huichun capsule. The disintegration time is remarkably shortened, the treatment efficacy is remarkably superior to that of Huichun capsules sold in the market, and a positive effect is obtained.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to a rejuvenation capsule and a preparation method thereof. Background technique [0002] Huichun Capsule nourishes the kidney, nourishes the essence, helps yang, and moistens dryness. It is used for lumbago due to kidney deficiency, mental fatigue and forgetfulness, impotence and impotence embolism. The commercially available Huichun Capsules have unsatisfactory curative effect due to the composition and process, and the preparation is prepared by traditional technology, which has the disadvantages of slow disintegration and low curative effect. Contents of the invention [0003] In order to overcome the above disadvantages, the present invention provides a rejuvenation capsule with fast disintegration speed and high curative effect and a preparation method thereof. [0004] Invention embodiment is as follows: [0005] Take 18g Gastrodia elata, 45g ferulae, 1.8g ge...

Claims

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Application Information

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IPC IPC(8): A61K36/8988A61K9/48A61K47/38A61P15/10A61P25/00
CPCA61K36/8988A61K9/4866A61K33/26A61K35/32A61K35/48A61K35/583A61K36/23A61K36/254A61K36/296A61K36/57A61K36/64A61K36/756A61K36/79A61K36/88A61K2236/15A61K2236/37A61K2300/00
Inventor 不公告发明人
Owner HEILONGJIANG JIANGHENG PHARMA TECH CO LTD
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