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A kind of removal method of ethoxyquinoline in lutein extract

A technology of ethoxyquinoline and lutein, applied in the direction of organic chemistry, can solve the problems of small processing capacity, low product yield, large amount of adsorbent, etc., and achieve large processing capacity, high product yield and process Simple operation effect

Active Publication Date: 2016-02-03
晨光生物科技集团腾冲有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the large amount of adsorbent and the direct use of the extract for adsorption, there will be disadvantages of low product yield and small processing capacity, making it difficult to industrialize production

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) After 1000kg of marigold flower granules were extracted with n-hexane, filtered and concentrated, 200 liters of lutein extract was obtained. After sampling, the content of the extract was 50%, and the total lutein content was 12000g. The content of ethoxyquinoline in the medium is 300ppb;

[0026] (2) Add 400 liters of methanol solution with a volume fraction of 45% to the lutein extract (adjust the pH of the methanol solution to 2.5 with phosphoric acid), and stir at 40°C for 35 minutes to obtain a mixed solution;

[0027] (3) The mixed solution is kept at 40°C in the separator for 1 hour, the mixed solution is layered into a n-hexane layer and a methanol layer, and the methanol layer is released;

[0028] (4), the n-hexane layer was washed 4 times according to steps (2) and (3);

[0029] (5), the upper n-hexane layer was washed with water to pH = 7;

[0030] (6) 100kg of lutein was obtained by concentrating the n-hexane layer, the total lutein content was 11940g...

Embodiment 2

[0032] (1) After 1500kg of marigold flower granules were extracted with n-hexane, filtered and concentrated, 250 liters of lutein extract was obtained. The content of the extract was 45% and the total lutein content was 13400g after sampling. The content of ethoxyquinoline in the medium is 500ppb;

[0033] (2) Add 750 liters of ethanol solution with a volume fraction of 48% to the lutein extract (adjust the pH of the ethanol solution to 2.2 with hydrochloric acid), and stir at 45°C for 50 minutes to obtain a mixed solution;

[0034] (3) The mixed solution is kept at 45°C in the separator for 1.5 hours, the mixed solution is layered into a n-hexane layer and an ethanol layer, and the ethanol layer is released;

[0035] (4) Wash the n-hexane layer 5 times according to steps (2) and (3);

[0036] (5), the upper n-hexane layer was washed with water to pH = 7;

[0037] (6) 112.5kg of lutein was obtained by concentrating the n-hexane layer, with a total lutein content of 13250g an...

Embodiment 3

[0039] (1) After 1000kg of marigold flower granules were extracted with n-hexane, filtered and concentrated, 750 liters of lutein extract was obtained. The content of the extract was 30% and the total lutein content was 12000g after sampling. The content of ethoxyquinoline in the medium is 700ppb;

[0040] (2) Add 750 liters of methanol solution with a volume fraction of 60% to the lutein extract (adjust the pH of the methanol solution to 4.0 with phosphoric acid), and stir at 35°C for 30 minutes to obtain a mixed solution;

[0041] (3) The mixture is kept at 35°C in the separator for 1 hour, the mixture is layered into a n-hexane layer and a methanol layer, and the methanol layer is released;

[0042] (4) Wash the n-hexane layer 6 times according to steps (2) and (3);

[0043] (5), the upper n-hexane layer was washed with water to pH = 7;

[0044] (6) The n-hexane layer was concentrated to obtain 100kg of lutein, the total lutein content was 11921g, and the content yield wa...

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Abstract

The invention relates to a method for removing ethoxyquinoline out of xanthophyll extract, belonging to the technical field of plant extracts. The method comprises the following steps: (1) performing normal hexane extraction, filtration and vacuum concentration on marigold flower granules, thus obtaining a xanthophyll extracting solution; (2) adding an alcohol-water solution into the xanthophyll extracting solution, stirring in a thermostatic water-bath with the temperature of 35-55 DEG C, thus obtaining a mixed solution; (3) layering: performing centrifugal layering or standing layering on the mixed solution at the temperature of 35-55 DEG C, discharging the lower alcohol solution layer, thus obtaining the upper normal hexane layer; (4) washing, namely washing the upper normal hexane layer with clear water till the pH value of the water layer is neutral; and (5) concentrating, namely concentrating the normal hexane layer, thus obtaining the xanthophyll extract without ethoxyquinoline. The method disclosed by the invention is easy to operate, high in treatment capacity and high in product yield, special equipment and special chemical reagents are not needed, the xanthophyll extract without ethoxyquinoline can be obtained, and industrial production is realized.

Description

technical field [0001] The invention belongs to the technical field of plant extracts, in particular to a method for removing ethoxyquinoline in lutein extract. Background technique [0002] Marigold flowers are harvested-enzymolysis-dehydration-drying-granulation-extraction-lutein extract. The lutein extract can be further processed to obtain a series of lutein products such as lutein crystals, lutein esters, and lutein microcapsules. [0003] Ethoxyquinoline, whose chemical name is 6-ethoxy-2,2,4-trimethyl-1,2-dihydroquinoline, is one of the feed antioxidants with excellent performance, and has certain mildew resistance and fresh-keeping effect; it can also be used as food antioxidant, fruit fresh-keeping agent, rubber anti-aging agent, and is currently widely used in the world. [0004] With the continuous progress of society and the improvement of people's living standards, while the market demand for lutein is increasing, people's requirements for product safety are g...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C403/24
Inventor 黄利勇李俊和贾五江韩文杰李凤飞
Owner 晨光生物科技集团腾冲有限公司
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