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Application of CMKLR1 micromolecule antagonist to control obesity and obesity metabolic syndrome

A technology for metabolic syndrome and antagonists, applied in the field of biomedicine, can solve problems such as side effects, and achieve the effects of simple synthesis, low cost and low cost

Inactive Publication Date: 2015-03-25
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Obesity is a chronic metabolic disorder, and the drugs currently in use have side effects in varying degrees

Method used

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  • Application of CMKLR1 micromolecule antagonist to control obesity and obesity metabolic syndrome
  • Application of CMKLR1 micromolecule antagonist to control obesity and obesity metabolic syndrome
  • Application of CMKLR1 micromolecule antagonist to control obesity and obesity metabolic syndrome

Examples

Experimental program
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Embodiment 1

[0027] The application of the CMKLR1 small molecule antagonist in the prevention and treatment of obesity and obesity metabolic syndrome; the CMKLR1 small molecule antagonist is α-NETA and its derivatives.

[0028] The obesity and obesity metabolic syndrome are fatty liver, diabetes and insulin disease.

[0029] The present invention uses the CMKLR1 small molecule antagonist as a chemokine receptor antagonist, inhibits the occurrence of obesity by inhibiting the Chemerin / CMKLR1 signaling pathway through the CMKLR1 small molecule antagonist, so as to achieve the purpose of preventing and treating obesity and obesity metabolic syndrome. The process does not have potential inflammatory response effects and has the advantage of being less expensive than producing small protein proteins. Specific steps are as follows:

[0030] (1) In vitro study: mouse 3T3-L1 preadipocytes were used to establish an adipocyte differentiation model. The sign of successful modeling is that after 1 da...

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PUM

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Abstract

The invention discloses application of a CMKLR1 micromolecule antagonist to control obesity and obesity metabolic syndrome, and the CMKLR1 micromolecule antagonist is alpha-NETA and derivatives thereof. According to the technical scheme, generation of obesity is inhibited by employing the CMKLR1 micromolecule antagonist as a chemokine-receptor antagonist to inhibit Chemerin / CMKLR1 signal pathway, and thus the purpose of controlling obesity and obesity metabolic syndrome is realized. The process does not possess potential inflammation response effect and possesses the advantage that the cost is lower than the cost of producing micromolecule protein. Alpha-NETA and derivatives thereof are relatively simple in synthesis and relatively low in cost, and have extremely good market application prospect on control of obesity and obesity metabolic syndrome.

Description

【Technical field】 [0001] The invention belongs to the technical field of biomedicine, and particularly relates to the application of CMKLR1 small molecule antagonists in preventing and treating obesity and obesity metabolic syndrome. 【Background technique】 [0002] Obesity, as a disease of energy metabolism, has attracted more and more attention from the world as a threat to human health. According to a report released by the International Obesity Conference, the number of deaths due to obesity in the world is more than twice that of those who died of starvation. Obesity has become a social problem. Obesity refers to a certain degree of obvious overweight and thick fat layer, which is a state caused by excessive accumulation of body fat, especially triglycerides. Excessive body fat accumulation due to excessive food intake or changes in body metabolism leads to excessive weight gain and pathological and physiological changes in the human body. Studies have confirmed that o...

Claims

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Application Information

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IPC IPC(8): A61K31/567A61P3/04A61P1/16A61P3/10A61P5/48
CPCA61K31/567A61K45/06
Inventor 张键孙钦策
Owner SHENZHEN INST OF ADVANCED TECH
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