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Computer assisted embryo selection method

A computer-aided, embryonic technology, applied in computing, special data processing applications, instruments, etc., can solve problems such as inaccurate data, achieve high developmental potential, and easy operation

Inactive Publication Date: 2015-03-25
LIUZHOU CITY HEALTHCARE HOSPITAL FOR WOMEN & CHILDREN
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  • Summary
  • Abstract
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  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In published academic papers, it is reported that the OCTAX Eye-ware software system is used to observe and record oocytes and embryos, but since the OCTAX Eye-ware software system is a system attached to the laser-assisted hatching equipment, the measured data is not accurate enough

Method used

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Embodiment 1

[0021] Example 1: A computer-aided embryo selection method, using Nikon NIS-Elements software (NIS-Elements Nikon image processing software) to collect oocyte images one by one before ICSI and during short-term fertilization and egg removal observation, and measure transparency The thickness of the zona pellucida, the diameter of the oocyte, and the size of the egg space at the position of the polar body are selected. The thickness of the zona pellucida is 16.9-20.7 μm, the diameter of the oocyte is 114.8-119.9 μm, and the egg space at the position of the polar body is 8.5-12.3 μm. The cells were fertilized; when accepting the observation of the embryo development stage, the pronuclear stage morphology, the number of blastomeres, the uniformity of blastomeres and embryo fragments were recorded respectively, and the embryos were scored. Fertilization was observed 16-20 hours after conventional fertilization, and cleavage was observed 42-43 hours after fertilization.

[0022] Th...

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Abstract

The invention relates to a computer assisted embryo selection method. Before ICSI is conducted and when short time insemination oocyte dismantling observation is conducted, Nikon NIS-Elements software is used for collecting oocyte images one by one, the thickness of a transparent tape, the diameter of oocytes and the oocyte gap of a polar body position are measured, and the oocytes with the thickness of the transparent tape being 16.9-20.7 microns, the diameter of the oocytes being 114.8-119.9 microns and the oocyte gap of the polar body position being 8.5-12.3 microns are selected for being subjected to insemination; then embryos with the high developmental potentiality are selected. According to the method, the Nikon NIS-Elements software is used for collecting the oocyte images one by one, the thickness of the transparent tape, the diameter of the oocytes and the oocyte gap of the polar body position are measured, the appropriate oocytes are selected for being subjected to insemination, and then the embryos with the high developmental potentiality are selected. According to the method, a layer of screening is added compared with the prior art, and the embryos with the high developmental potentiality can be better obtained. The data obtained by using the Nikon NIS-Elements software for measuring and analyzing are more accurate.

Description

technical field [0001] The invention relates to a computer-aided embryo selection method. Background technique [0002] The success rate of in-vitro fertilization-embryo transfer (in-vitro fertilization, IVF-ET) and oocyte single sperm injection (intra-cytoplasmic sperm injection, ICSI) in the treatment of infertility mainly depends on the internal uterine environment and the quality and quality of transplanted embryos. number. Studies have proved that the selection of embryo quality assessment can help reduce multiple pregnancy, improve implantation rate and clinical pregnancy rate. Evaluating whether embryos have high implantation potential is the focus of modern assisted reproductive technology. The main parameters used to evaluate embryo quality are pronuclear stage score and cleavage stage embryo morphology and development speed. [0003] At present, in clinical practice, embryo grading is mainly based on subjective light microscopic morphological analysis, including ...

Claims

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Application Information

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IPC IPC(8): G06F17/50
Inventor 李楠王春霞韦继红韦立红王麟唐永梅牟联俊秦祖兴
Owner LIUZHOU CITY HEALTHCARE HOSPITAL FOR WOMEN & CHILDREN
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