A kind of sheet-like hydrogel material and preparation method thereof

A hydrogel and sheet technology, applied in the chemical field, can solve the problems of inconvenient movement, inability to prepare, and high fluidity, achieve high biocompatibility and safety, avoid uneven sheet thickness, and improve material liquid The effect of viscosity

Active Publication Date: 2017-02-22
长春吉原生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] 1. Due to the low viscosity and high fluidity of the material liquid, it is not easy to move after the mold is injected with the material liquid;
[0006] 2. Due to the movement and inclination of the mold, the injection molding-radiation process cannot prepare thinner sheets;
[0007] 3. The synthesis time of the freeze-thaw process is long, and the energy consumption is high, resulting in an increase in cost;
[0008] 4. The freeze-thaw process will reduce the transparency of the hydrogel material

Method used

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  • A kind of sheet-like hydrogel material and preparation method thereof
  • A kind of sheet-like hydrogel material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] According to the components in Table 1, put the raw materials into the reaction equipment with stirring and heating functions, according to the process parameters given in the attached table 2, the reaction equipment is heated to 95 ° C and stirred until the feed liquid is a transparent, viscous solution, Transfer the material liquid to the material cylinder and place it. After the temperature of the material liquid drops to 20°C, the material liquid is applied between the two layers of release films through the coating equipment, and the coating thickness is 3 mm. The obtained sheet was refrigerated in a refrigerating device, the refrigerating temperature was 0 °C, and the refrigerating time was 8 h, the sheet was pre-formed, and the pre-formed sheet was irradiated by an electron accelerator. The irradiation times were 3 times, the radiation-formed sheet was cut, packed into a package, and sterilized by radiation. The sterilization dose was 10 kGy each time, and the irr...

Embodiment 2-10

[0039] According to the method described in Example 1, the hydrogel sheet was prepared according to the material liquid formula given in Table 1 and the synthesis process parameters given in Table 2, respectively, to obtain the hydrogel sheet.

[0040] The sheet-like hydrogel materials prepared according to Examples 1-10 all have the following performance characteristics: the water content reaches 65%-90%, the visible light transmittance is more than 80%, the cytotoxicity is less than or equal to grade 2, and there is no skin irritation. No skin sensitization, the difference in sheet thickness is less than or equal to 0.05mm, and can be used in the production of wound care dressings and beauty care products.

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Abstract

The invention relates to a sheet-like hydrogel material and a preparation method thereof, wherein the sheet-like hydrogel material is composed of the following raw materials according to the percentage of the total weight of the raw materials: polyvinyl alcohol accounts for 4-18%, polyethylene Pyrrolidone accounts for 0-12%, polyethylene oxide accounts for 0-2%, sodium alginate accounts for 0-3%, chitosan accounts for 0-0.5%, xanthan gum accounts for 0-1.5%, sodium polyacrylate accounts for 0-1.5% %, water accounts for 69.99‑93.5%. The preparation method of the sheet-shaped hydrogel material is as follows: heat up the raw material and stir it into a transparent and viscous solution, take it out and cool it down and apply it between two layers of release film, preform it in low temperature refrigeration, form it by electron accelerator radiation, cut it and packed into packages, sterilized by radiation to obtain the sheet-shaped hydrogel material. The hydrogel sheet prepared by this method has high water content, biocompatibility and safety, and the thickness uniformity of the sheet is greatly improved compared with the current technology; the preparation method is simple and easy, and the production efficiency High, low production energy consumption, and can be applied to large-scale production of hydrogel sheets.

Description

technical field [0001] The invention relates to a sheet-like hydrogel material and a preparation method thereof, belonging to the field of chemistry. Background technique [0002] Hydrogel is a kind of polymer compound with a three-dimensional space network structure, which can swell, absorb and release water in large quantities and maintain the original structure and form. Because of its good water retention performance and adjustable mechanical properties, it is widely used in agriculture. , industry, construction, medical care industry and other fields. Hydrogel materials can be synthesized by physical and chemical methods. The spatial grid structure of hydrogels synthesized by physical synthesis method is formed by intermolecular force or entanglement of molecular chains, and its morphology and performance stability are poor at high temperature or other special conditions, which limits its application field. Chemically synthesized hydrogel materials are prepared by add...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61L15/42A61L15/24A61L15/26A61L15/28A61K8/86A61Q19/00
Inventor 王靖哲荆晶余航于春暖王栗陈亮
Owner 长春吉原生物科技有限公司
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