Composite antimicrobial liquid soap and preparation method thereof

An antibacterial hand sanitizer and composite technology, applied in the field of hand sanitizer, can solve the problems of poor solubility, poor antibacterial ability of simple plant extracts, and great influence on product properties, so as to improve product stability and volatility, improve skin care and Bactericidal effect, overcoming the effect of weak bactericidal effect

An antibacterial hand sanitizer and composite technology, applied in the field of hand sanitizer, can solve the problems of poor solubility, poor antibacterial ability of simple plant extracts, and great influence on product properties, so as to improve product stability and volatility, improve skin care and Bactericidal effect, overcoming the effect of weak bactericidal effect

CN104490679AActive Publication Date: 2015-04-08张鹏志
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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0015] The invention provides a preparation method of a compound antibacterial hand sanitizer. Add 0.2-0.6g of olive leaf extract into water at 22-28°C, stir evenly, add 20-30ml of glycerol, and add deionized water to set Make up to 70-80ml, heat to 45-50°C and shake at constant temperature for 8-12h, then lower the temperature to 22-28°C, add 20-30ml of ethanol with a mass concentration of 98-99.7% and 0.05-0.1g of dichlorobenzene Oxychlorophene is evenly stirred, and the pH value is adjusted to 6-8 to obtain a compound antibacterial hand sanitizer, and the olive leaf extract is an olive leaf extract containing oleuropein with a mass concentration of 30-40%.

[0016] The principle of the present invention is: oleuropein in the olive leaf extract of the present invention is the main antibacterial active substance, has high safety, low market price, and has anti-Gram-negative and positive bacterial effects, and is effective against typhoid Salmonella Bacteria, Escherichia coli ...

Embodiment 1

[0031]Take 0.2g of olive leaf extract containing 35-40% oleuropein in mass concentration, mix it with deionized water at room temperature, stir it magnetically for 1 hour, add 20ml glycerol, set the volume to 70ml, heat to 45°C, Vortex the beaker overnight (8h), cool down to room temperature, add 30ml of 99.7% ethanol, add 0.1g of dichlorophenoxychlorophen, mix and stir for 1h, adjust the pH value to 6-8 with citric acid, and obtain the compound type of this embodiment Antibacterial hand sanitizer. The obtained compound antibacterial hand sanitizer is clear, transparent, and volatilizes quickly. It is selected as the subject of skin irritation experiment and toxicology experiment for testing. The test results show that the compound antibacterial hand sanitizer of this embodiment has a bacteriostatic rate>90%, and a bactericidal rate>99.9%.

Embodiment 2

[0033] Only glycerol was heated to 50° C., 0.05 g of dichlorophenoxychlorophen was added, and the mass concentration of ethanol was 98%, and the remaining conditions were the same as in Example 1.

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Abstract

The invention relates to a preparation method of a composite antimicrobial liquid soap, which comprises the following steps: adding 0.2-0.6g of olive leaf extract into water at 22-28 DEG C, stirring uniformly, adding 20-30ml of glycerol, adding deionized water to 70-80ml, heating to 45-50 DEG C, oscillating at constant temperature for 8-12 hours, cooling to 22-28 DEG C, adding 20-30ml of 98-99.7 wt% ethanol and 0.05-0.1g of triclosan, stirring uniformly, and regulating the pH value to 6-8, thereby obtaining the composite antimicrobial liquid soap, wherein the mass content of the olive glycoside in the olive leaf extract is 30-40%. The invention also relates to a composite antimicrobial liquid soap. The composite antimicrobial liquid soap has the advantages of no toxicity, high antimicrobial property, favorable volatility, high stability and skin care.

Description

technical field [0001] The invention relates to a hand sanitizer, in particular to a composite antibacterial hand sanitizer and a preparation method thereof. Background technique [0002] Epidemiological and epidemiological studies have found that most infectious diseases can be mediated through hands as a transmission route. In addition, the hands of hospital medical staff are an important cause of nosocomial infections. Therefore, reasonable hand disinfection is the key to controlling nosocomial infections and infections. important method of disease transmission. [0003] In the past, people used soap as a hand washing product. Soap has the characteristics of poor usability and serious cross-contamination, which easily leads to secondary pollution. At present, soap is gradually being replaced by hand sanitizers in public places. Hand sanitizers have the function of cleaning and skin care, and adding specific ingredients in them can play a role in disinfection and sterili...

Claims

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Application Information

Patent Timeline
08 Apr 2015
Publication
CN104490679A
IPC
A61K8/97; A61K8/34; A61Q19/10; A61P31/04; A61P31/02; A61Q19/00
Inventors
李宏