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Stable high-efficiency anticoccidial drug decoquinate solution and preparation process thereof

A technology of decoquinate and anticoccidia, which is applied in the field of anticoccidial drugs, and can solve the problems that decoquinate cannot exert an anti-coccidial effect well, the bioavailability is not high, and it cannot be administered with drinking water. Achieve the effect of stable solution quality, good anti-coccidian effect and accurate dosage

Inactive Publication Date: 2015-04-22
ZHENGZHOU FUYUAN ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Since decoquinate is highly fat-soluble and extremely difficult to dissolve in water and general organic solvents, the current common decoquinate premix cannot be administered with drinking water, and after the premix is ​​administered, it will enter the body The bioavailability is not high, resulting in decoquinate not being able to play an anti-coccidial effect well

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] (1) Mix decoquinate 3%, dimethylformamide 75%, polyethylene glycol 200 1.0%, polyethylene glycol 400 1.0%, dimethyl sulfoxide 14%, and magnesium chloride 6%;

[0019] (2) Get 80% of the above mixed solution and heat it to 80°C, add magnesium chloride and stir until dissolved;

[0020] (3) Continue heating to 130°C, add decoquinate and stir for 10 minutes to make it all dissolve;

[0021] (4) Use the remaining 20% ​​mixed solution to make up volume, cool, and pack to obtain the decoquinate solution.

Embodiment 2

[0023] (1) Mix decoquinate 3%, dimethylformamide 78%, polyethylene glycol 200 1.0%, polyethylene glycol 400 0.5%, dimethyl sulfoxide 9.5%, and magnesium chloride 8%;

[0024] (2) Get 80% of the above mixed solution and heat it to 90°C, add magnesium chloride and stir until dissolved;

[0025] (3) Continue heating to 140° C., add decoquinate and stir for 6 minutes to completely dissolve it;

[0026] (4) Use the remaining 20% ​​mixed solution to make up volume, cool, and pack to obtain the decoquinate solution.

Embodiment 3

[0028] (1) Mix decoquinate 3%, dimethylformamide 80%, polyethylene glycol 200 1.0%, polyethylene glycol 400 0.5%, dimethyl sulfoxide 10%, and magnesium chloride 5.5%;

[0029] (2) Take 80% of the above mixed solution and heat it to 95°C, add magnesium chloride and stir until dissolved;

[0030] (3) Continue heating to 135° C., add decoquinate and stir for 8 minutes to make it all dissolve;

[0031] (4) Use the remaining 20% ​​mixed solution to make up volume, cool, and pack to obtain the decoquinate solution.

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PUM

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Abstract

The invention discloses a stable high-efficiency anticoccidial drug decoquinate solution and a preparation process thereof. The stable high-efficiency anticoccidial drug decoquinate solution comprises the following components in percentage by weight: 3% of main drug decoquinate, 75%-85% of dimethyl formamide, 0.5%-1.0% of polyethylene glycol 200, 0.5%-1.0% of polyethylene glycol 400, 7%-14% of dimethyl sulfoxide and 2%-8% of magnesium chloride. The preparation process of the stable high-efficiency anticoccidial drug decoquinate solution comprises the following steps of mixing the dimethyl formamide, polyethylene glycol 2000, polyethylene glycol 4000 and the dimethyl sulfoxide, and heating 80% of mixed solutions to 80-100 DEG C; adding magnesium chloride, stirring for dissolution, and further heating to 120-150 DEG C; adding the decoquinate, and stirring for 5-10 minutes for complete dissolution; then fixing volume by using the rest of 20% of the mixed solutions, cooling, and subpackaging to obtain the decoquinate solution. The stable high-efficiency anticoccidial drug decoquinate solution disclosed by the invention has the advantages of stable solution quality, simple and controllable production process and accurate dosage, and is convenient for drinking administration.

Description

technical field [0001] The invention relates to a stable and efficient anticoccidial drug decoquinate solution and a preparation process thereof. Background technique [0002] Decoxyquinate, as a new type of quinoline anticoccidial drug, was first developed by the British May-Baker Company. Due to its excellent anticoccidial and weight gain effects, it has been widely used in North America and Europe. Although decoquinate has been widely used abroad, it was not until 2006 in China that Yalai Company of the United States sold decoquinate for the first time, and the product attracted great attention and widespread attention as soon as it was launched. At present, its clinical application is mainly 60g / kg decoquinate premix, which is mainly used for the prevention and treatment of coccidiosis. [0003] Decoxyquinate is (Decoquinate), the chemical name is 6-decyloxy-7-ethoxyl-4-hydroxyquinoline-3-carboxylate ethyl ester, and its broad-spectrum anticoccidial activity makes it a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/47A61K47/18A61K47/20A61K47/34A61P33/02
Inventor 王树槐袁宝青李红娇黄向丽
Owner ZHENGZHOU FUYUAN ANIMAL PHARMA